supported by the National Science Foundation of China(No.81072701);Natural Science Foundation of Guangdong Province(No.10151008002000002/S2011010005830);key project of China(No.S2012020010947)
Background Clopidogrel is an antiplatelet drug, which requires the effiux pump P-glycoprotein (multidrug resistance-1, MDR1) encoded by the ABCB1 gene for intestinal absorption. However, recent studies evaluating th...
supported by Medical scientific research Planning Project of Qingdao Shandong Province(No.2014-WJZD048)
Background Compared to clopidogrel, Ticagrelor significantly reduces the risk of cardiovascular events in patients with acute myocardial infarction (AMI) however increases the incidence of bleeding and the risk of f...
supported by Medical Scientific Research Foundation of Guangdong Province(No.A2010043)
Background In clopidogrel-treated patients undergoing percutaneous coronary intervention (PCI), the effect of concomitant use of PPIs on prognosis remains unclear. Methods From July 2010 to June 2012, 600 patients a...
supported by Medical Research Foundation of Guangdong Province(No.B2011008)
Background For patients with prosthetic heart valves, thrombosis of the valves is dangerous. A second surgery for re-replacing the thrombosed valve is quite traumatic. There have been some researches on noninva-sive t...
INTRODUCTION Dual antiplatelet therapy with aspirin and clopidogrel plays a key role in preventing recurrent atherothrombotic events in patients with acute coronary syndromes and those undergoing coronary stent implan...
Background Despite the proven benefit of 600-mg loading dose of clopidogrel in patients with acute ST- segment elevation myocardial infarction (STEMI) who undergo primary percutaneous cronary intervention (PCI), t...
Background Impact of dual antiplatelet therapy beyond 12 months on patients implanted with DES remains unsolved.Methods From January 2010 to June 2011,1873 patients who have been taking DAPT and free from death,myocar...
Background Clopidogrel is beneficial after acute coronary syndrome. Recent studies suggest the superiority of prasugrel compared with clopidogrel. The enhanced platelet inhibition with prasugrel lead to a reduction in...
Objectives To investigate the inhibitory effect of clopidogrel on release of soluble CD40 ligand (sCD40L) by ADP-activated platelet in patients with non-ST-segment elevation acute coronary syndromes(NSTEACS). Meth...
Objectives To investigate the change and clinical significance of clopidogrel on platelet membrane CD40L in coronary artery disease patients before and after percutaneous coronary intervention(PCI). Methods 30 cases w...