CYTOCHROME_P450

作品数：271被引量：809H指数：13
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Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity
《Journal of Pharmaceutical Analysis》2023年第12期1510-1525,共16页Shuai Zhang Tingting Wang Ye Feng Fei Li Aijuan Qu Xiuchen Guan Hui Wang Dan Xu 
supported in part by grants from the National Natural Science Foundation of China(Grant Nos.:81973405,82122071,and 82030111)to Dan Xu;Hui Wang,the National Key R&D Program of China(Grant No.:2020YFA0803900)to Hui Wang;the Hubei Provincial Natural Science Foundation Outstanding Youth Found,China(Grant No.:2022CFA083).
The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme(CYP),which plays a crucial role in the metabolism of neurosteroids.The antiepileptic dr...
关键词：Pregnenolone 16a-carbonitrile Pregnane X receptor Hippocampus Glucocorticoid receptor Phenytoin sodium NEUROTOXICITY 
Spectroscopic studies of the interaction between phosphorus heterocycles and cytochrome P450
《Journal of Pharmaceutical Analysis》2021年第6期757-763,共7页Dumei Ma Libo Zhang Yingwu Yin Yuxing Gao Qian Wang 
supported by the China Scholarship Council and Fujian University-Industry Research Cooperation Project(Project No.:2018N5013)。
P450 fatty acid decarboxylase Ole T from Staphylococcus aureus(Ole TSA)is a novel cytochrome P450 enzyme that catalyzes the oxidative decarboxylation of fatty acids to yield primarily terminal alkenes and CO_(2) or mi...
关键词：Phosphorus heterocycles Cytochrome P450 Ole T INTERACTION SPECTROSCOPY 
Screening of the whole human cytochrome P450 complement(CYPome)with enzyme bag cocktails被引量：2
《Journal of Pharmaceutical Analysis》2020年第3期271-276,共6页Sangeeta Shrestha Sharma Shishir Sharma Matthias Bureik 
We have previously introduced the use of permeabilized fission yeast cells(enzyme bags)that recombinantly express full-length CYPs for drug metabolism studies.Such enzyme bags are cells with pores that function as enz...
关键词：Cytochrome P450 Drug metabolism Fission yeast LUMINESCENCE Proluciferin 
An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes被引量：6
《Journal of Pharmaceutical Analysis》2014年第4期270-278,共9页Jing-Jing Wang Jian-Jun Guo Jenny Zhan Hai-Zhi Bu Jiunn H.Lin 
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 （CYP） enzymes. This method employed a cocktail of six probe sub...
关键词：LC-MS/MS Cytochrome P450 Cocktail-probe Inhibition assessment Drug screenning 
Genetic polymorphism of T6235C mutation in 3' non-coding region of CYP1A1 and GSTM1 genes and lung cancer susceptibility in the Mongolian population
《Journal of Pharmaceutical Analysis》2009年第4期225-229,共5页Fu-hou Chang1,Min-jie Wang1,Jun Qi1,Qin Yin1,Lei Fan1,Rui-lan Han1,Guang Wang2 1.Department of Pharmacology,Inner Mongolia Medical College,Huhhot 010059 2.the First Affiliated Hospital,Inner Mongolia Medical College,Huhhot 010059,China 
supported by the National Natural Science Foundation of China(No.30661021);the Natural Science Foundation of Inner Mongolia Autonomous Region(No.200607010907);Doctor Initializing Fund Application of Inner Mongolia Medical College(No.2005BQ001)
Objective To estimate the relative risk for lung cancer associated with genetic polymorphism of T6235C mutation in 3’ non-coding region(MspⅠ)of cytochrome P450 1A1(CYP1A1)and glutathione S-transferase M1(GSTM1)in th...
关键词：polymorphism GENOTYPE lung cancer cytochrome P450 glutathione S-transferase Mongolian in China 
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