DROSHA

作品数：43被引量：111H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：柳满然张海龙况燕田小波徐丽云更多>>
相关机构：重庆医科大学华中科技大学中国科学院上海生命科学研究院上海海洋大学更多>>
相关期刊：《天津医药》《现代生物医学进展》《Acta Pharmacologica Sinica》《科学新闻》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划教育部“新世纪优秀人才支持计划”湖北省卫生厅科研基金更多>>
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Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells被引量：14
《Cell Research》2021年第3期345-361,共17页Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu 
supported by the National Key R&D Program of China(2019YFA0110300 to Q.Liu and 2017YFA0505600-04 to Q.Liu);the National Natural Science Foundation of China(81820108024 to Q.Liu,81630005 to Q.Liu,81972786 to J.X.,81573025 to Q.Liu,81703062 to L.H.and 81703091 to F.A.);Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(IRT_17R15);Innovative Research Team in University of Liaoning(LT2017001 to Q.Liu);the Natural Science Foundation of Liaoning(2019-BS-081 to F.P.);the"Seedling cultivation"program for young scientific and technological talents of Liaoning(LZ2019067 to B.C.and 2020 to F.P.);the program for climbing Scholars of Liaoning,the Science and Technology Innovation Foundation of Dalian(2020JJ25CY008 to Q.Liu);Dalian High-level Talent Innovation Program(2016RD12 to Q.Liu);International Scientific and Technological Cooperation of Dalian(2015F11GH095 to Q.Liu);the Natural Science Foundation of Guangdong(2016A030311038 and 2017A030313608 to Q.Liu,2017A020215098 to Z.W.);the Science and Technology Planning Project of Guangzhou(201804020044 to Q.Liu);E.W-F.L/s work is supported by MRC(MR/N012097/1);CRUK(C37/A12011;C37/18784);Breast Cancer Now(2012MayPR070;,2012NovPhD016,2014NovPhD326)。
RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage...
关键词：DROSHA AURKA BREAST 
Drosha and Dicer： Slicers cut from the same cloth
《Cell Research》2016年第5期511-512,共2页Sisi Li Dinshaw J Patel 
DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex...
关键词：DICER 切片机 微处理器 RNA合成 异三聚体 合作伙伴 末端区域 裂解活性 
Modulation of microRNA processing by mismatch repair protein MutLa被引量：4
《Cell Research》2012年第6期973-985,共13页Guogen Mao Sanghee Lee Janice Ortega Liya Gu Guo-Min Li 
MicroRNAs （miRNAs） are critical post-transcriptional regulators and are derived from hairpin-snaped primary transcripts via a series of processing steps. However, how the production of individual miRNAs is regulated...
关键词：mismatch repair MLH1 MutLa MIRNA DROSHA DGCR8 3＇-UTR 
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