This work was supported in part by the grants from the National Natural Science Foundation of China(Nos.31470435 and 31570843).
A large number of proteins involved in RNA metabolism possess a double-stranded RNA-binding domain(dsRBD),whose sequence variations and functional versatilities are still being recognized.All dsRBDs have a similar str...
supported by the National Key R&D Program of China(2019YFA0110300 to Q.Liu and 2017YFA0505600-04 to Q.Liu);the National Natural Science Foundation of China(81820108024 to Q.Liu,81630005 to Q.Liu,81972786 to J.X.,81573025 to Q.Liu,81703062 to L.H.and 81703091 to F.A.);Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(IRT_17R15);Innovative Research Team in University of Liaoning(LT2017001 to Q.Liu);the Natural Science Foundation of Liaoning(2019-BS-081 to F.P.);the"Seedling cultivation"program for young scientific and technological talents of Liaoning(LZ2019067 to B.C.and 2020 to F.P.);the program for climbing Scholars of Liaoning,the Science and Technology Innovation Foundation of Dalian(2020JJ25CY008 to Q.Liu);Dalian High-level Talent Innovation Program(2016RD12 to Q.Liu);International Scientific and Technological Cooperation of Dalian(2015F11GH095 to Q.Liu);the Natural Science Foundation of Guangdong(2016A030311038 and 2017A030313608 to Q.Liu,2017A020215098 to Z.W.);the Science and Technology Planning Project of Guangzhou(201804020044 to Q.Liu);E.W-F.L/s work is supported by MRC(MR/N012097/1);CRUK(C37/A12011;C37/18784);Breast Cancer Now(2012MayPR070;,2012NovPhD016,2014NovPhD326)。
RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage...