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Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses被引量：3
《Science Bulletin》2018年第3期176-186,共11页guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li 
supported by the National Natural Science Foundation of China(31472215,31521005,31422054,31402206);the National Key R&D Program of China(2016YFD0500205)
The generation and application of replication-competent influenza A virus （IAV） expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new coun- termeasur...
关键词：Replication-competent Influenza A virus H5N1 H7N9 H9N2 Venus 
Generation of mutants with developmental defects in zebrafish by ENU mutagenesis被引量：1
《Chinese Science Bulletin》2004年第20期2154-2158,共5页JINPeng TIANTian SUNZhihui MENGAnming 
As a good model for studying early develop-ment of vertebrates, zebrafish (Danio rerio) is attracting more and more attention. Following ENU mutagenesis, 320 F2 families were established. Mutants, which showed defects...
关键词：突变异种 斑马鱼 ENU诱变 脊椎动物 晶胚 
Large-scale screening of disease model through ENU mutagenesis in mice被引量：1
《Chinese Science Bulletin》2003年第24期2665-2671,共7页HEFang WANGZixing ZHAOJing BAOJie DINGJun RUANHaibin XIEQing ZHANGZuoming GAOXiang 
supported by the State“863”High-Tech Project and the National Gongguan Project
Manipulation of mouse genome has merged as one of the most important approaches for studying genefunction and establishing the disease model because of the high homology between human genome and mouse genome. In this ...
关键词：ENU 基因突变 染色体 形态学 心电图 
Four kinds of ENU-induced white spot mice and chromosome locations of the mutant genes被引量：11
《Chinese Science Bulletin》2003年第24期2658-2664,共7页WU Baojin1,2, MAO Huihua1, SHAO Yixiang1, XUE Zhengfeng1 & LI Houda1 1. Comparative Medicine Center of Yangzhou University, Yangzhou 225009, China 2. Medical College of Yangzhou University, Yangzhou 225001, China Correspondence should be addressed to Li Houda (e-mail: houdali @yahoo.com.cn) 
Phenotype-driven is the name for an ap-proach used to study gene functions through mutagenesis, location and cloning of the mutant gene. In this study, 150 male C57BL/6J(B6) mice were treated with ENU and repro-duced ...
关键词：染色体 突变基因 基因工程 ENU 
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