supported by the National Natural Science Foundation of China(22125108 and 22121001 for Ye LW,22122109 and 22271253 for Hong X);the National Key R&D Program of China(2022YFA1504301,Hong X);the Zhejiang Provincial Natural Science Foundation of China(LDQ23B020002,Hong X);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SNZJU-SIAS-006,Hong X);the Beijing National Laboratory for Molecular Sciences(BNLMS202102,Hong X);the CAS Youth Interdisciplinary Team(JCTD-2021-11,Hong X);the Fundamental Research Funds for the Central Universities(226-2022-00140,226-2022-00224,and 226-2023-00115,Hong X);the State Key Laboratory of Physical Chemistry of Solid Surfaces(202210,Hong X);the Leading Innovation Team grant from the Department of Science and Technology of Zhejiang Province(2022R01005,Hong X);the Natural Science Foundation of Jiangsu Province(BK20211059);National Found for Fostering Talents of Basic Science(NFFTBS,J1310024).
Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for ...