funded by Consejería de Educación,Juventud y Deporte,Comunidad de Madrid,through the Atracción de Talento program(2022-5A/BMD-24221);Ministerio de Ciencia e Innovación(PDI2020-1153-70RB-100/AEI/10.13039/501100011033)to SC;JAMG is supported by Instituto de Salud CarlosⅢthrough the projects INT20/00079(co-funded by European Regional Development Fund:A way to make Europa)and INT23/00017.
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant,misfolded and mislocalized deposits of the protein TDP-43,as in the case of amyotrophic lateral scler...
JWV acknowledges funding from the NIH(T32MH019112);the SciLifeLab&Wallenberg Data Driven Life Science Program(Grant:KAW 2020.0239);Jeffrey S.Phillips was supported by NIH Grant(R01-AG054519,K01-AG061277);supported by NIH funding(P30 AG072979,P01AG066597,R01NS109260);Penn Institute on Aging,Robinson Family Fund,Peisach Family Fund for FTD Research,and Arking Family Fund.
Background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibit...
the National Natural Science Foundation of China to C.L.(No.32071188);Guangdong Basic and Applied Basic Research Foundation to C.L.(No.2020A1515010034);the Research Grants Council of the Hong Kong Special Administrative Region,China to G.Z.(Project No.16103719,16101120,and 161011121,AoE/M-403-16,AOE/M-401/20);Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)to G.Z.(Project No.SMSEGL20SC01eH)and VPRDO19RD03-6.
The abnormal expansion of G-rich hexanucleotide repeat,GGGGCC(G4C2),in chromosome 9 open reading frame 72(C9orf72)is known to be the prevailing genetic cause of two fatal degenerative neurological diseases,amyotrophic...
The present study aimed to identify risk factors among older adult drivers from realistic data in order to stimulate the development of appropriate safety measures in the future.For this purpose,N=400 archived case fi...
This study was supported by grants from the Swedish FTD initiative funded by the Schörling Family Foundation and the KTH Center for Applied Precision Medicine(KCAP)funded by the Erling-Persson Family Foundation.CG,LO and AU were further supported by grants from JPND Prefrontals Swedish Research Council(VR)529-2014-7504,Swedish Research Council(VR)2015-02926,Swedish Research Council(VR)2018-02754,Swedish Brain Foundation,Swedish Alzheimer Foundation,Stockholm County Council ALF,Karolinska Institutet Doctoral Funding and StratNeuro,Swedish Demensfonden.The authors acknowledge support from the National Genomics Infrastructure in Stockholm/Uppsala funded by Science for Life Laboratory,the Knut and Alice Wallenberg Foundation and the Swedish Research Council,and SNIC/Uppsala Multidisciplinary Center for Advanced Computational Science for assistance with massively parallel sequencing and access to the UPPMAX computational infrastructure.Open access funding provided by Royal Institute of Technology.
Background The clinical presentations of frontotemporal dementia(FTD)are diverse and overlap with other neurological disorders.There are,as of today,no biomarkers in clinical practice for diagnosing the disorders.Here...