GENOMIC

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Genomic insights into demographic history,structural variation landscape,and complex traits from 514 Hu sheep genomes
《Journal of Genetics and Genomics》2025年第2期245-257,共13页Kaiyu Chen Yuelang Zhang Yizhe Pan Xin Xiang Chen Peng Jiayi He Guiqing Huang Zhengguang Wang Pengju Zhao 
supported by grants from the Zhejiang Science and Technology Department Project(2023C04004);Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(2021C02068-6);Department of Science Technology of Huzhou City(2023GZ33);Zhejiang Team Technology Ambassador Project(Tongxiang);the National Natural Science Foundation of China(32172724).
Hu sheep is an indigenous breed from the Taihu Lake Plain in China,known for its high fertility.Although Hu sheep belong to the Mongolian group,their demographic history and genetic architecture remain inconclusive.He...
关键词：Hu sheep Population sequencing Demographic history Structural variation Genome-wide association study 
Reconstructing cell lineage trees with genomic barcoding:approaches and applications
《Journal of Genetics and Genomics》2024年第1期35-47,共13页Zizhang Li Wenjing Yang Peng Wu Yuyan Shan Xiaoyu Zhang Feng Chen Junnan Yang Jian-Rong Yang 
supported by the National Key Research and Development Program of China(2021YFF1200904,2021YFA1302500 to J.-R.Y.);the National Natural Science Foundation of China(32122022,31871320 to J.-R.Y.);by Science and Technology Planning Project of Guangdong Province,China(2014A030304053 to X.Z.).
In multicellular organisms,developmental history of cell divisions and functional annotation of terminal cells can be organized into a cell lineage tree(CLT).The reconstruction of the CLT has long been a major goal in...
关键词：Cell lineage tree Developmental regulation BIOTECHNOLOGY Computational biology 
Deciphering the evolution and complexity of wheat germplasm from a genomic perspective被引量：5
《Journal of Genetics and Genomics》2023年第11期846-860,共15页Zihao Wang Lingfeng Miao Yongming Chen Huiru Peng Zhongfu Ni Qixin Sun Weilong Guo 
supported by the National Natural Science Foundation of China(32272124,31991210)and the 2115 Talent Development Program.
Bread wheat provides an essential fraction of the daily calorific intake for humanity.Due to its huge and complex genome,progress in studying on the wheat genome is substantially trailed behind those of the other two ...
关键词：Wheat genomics EVOLUTION Wheat germplasm Multi-omics Databases and tools 
The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions
《Journal of Genetics and Genomics》2023年第10期776-785,共10页Ying Feng Li Guo Chen Yang Hui Zheng Xiao Xiao Hanhui Ma 
This work was funded by the National Natural Science Foundation of China(No.31970591 to H.Ma),the Shanghai Pujiang Program(19PJ1408000 to H.Ma);the Shanghai Science and Technology Innovation Action Plan(21JC1404800 to H.Ma);We thank Luke Lavis(Janelia Research Campus,Howard Hughes Medical Institute,Ashburn,VA,USA)for providing the HaloTag JF-549.U2OS Genomic DNA was a gift from Xingxu Huang.We thank Pengwei Zhang and Shuangli Zhang for their help with cell sorting.
The human genome can be demarcated into domains based on distinct epigenetic states.The trimethylation of histone H3 lysine 9(H3K9me3)is essential for the formation of constitutive heterochromatin nanodomains.However,...
关键词：H3K9me3 HP1α Chromatin dynamics Genomic interaction Epigenetic perturbation 
Genomic allele-specific base editing with imperfect gRNA
《Journal of Genetics and Genomics》2023年第10期799-802,共4页Xuxu Chen Dongdong Zhao Xueting Hou Ju Li Shiming Pu Jidong Fei Siwei Li Zuping Zhou Changhao Bi Xueli Zhang 
This work was financially supported by the National Key Research and Development Program of China(2018YFA0904900);the National Natural Science Foundation of China(32225031,32171449,81903776);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-017);the Tianjin Natural Science Foundation(20JCYBJC00310);the Youth Innovation Promotion Association CAS(2022177).
CRISPR base editor(BE)techniques are a promising tool for precise cytosine(C)to thymine(T),adenine(A)to guanine(G),and C to G base editing(CBE,ABE,and GBE,respectively)without the use of a donor DNA template conversio...
关键词：BASE A GENOMIC 
Genomic and transcriptomic analyses enable the identification of important genes associated with subcutaneous fat deposition in Holstein cows被引量：3
《Journal of Genetics and Genomics》2023年第6期385-397,共13页Hailiang Zhang Siyuan Mia Luiz F.Brito Lirong Hu Lei Wang Longgang Ma Qing Xu Gang Guo Ying Yu Yachun Wang 
the support of founding by the Key Research Project of Ningxia Hui Autonomous Region(2022BBF02017);the earmarked fund for CARS-36;the Program for Changjiang Scholar and Innovation Research Team in University(IRT-15R62)。
Subcutaneous fat deposition has many important roles in dairy cattle,including immunological defense and mechanical protection.The main objectives of this study are to identify key candidate genes regulating subcutane...
关键词：BOVINE Body condition score Subcutaneous adipose GWAS WGCNA RNA-Seq 
Molecular cytogenetic map visualizes the heterozygotic genome and identifies translocation chromosomes in Citrus sinensis被引量：1
《Journal of Genetics and Genomics》2023年第6期410-421,共12页Shipeng Song Hui Liu Luke Miao Li He Wenzhao Xie Hong Lan Changxiu Yu Wenkai Yan Yufeng Wu Xiao-peng Wen Qiang Xu Xiuxin Deng Chunli Chen 
supported by the National Natural Science Foundation of China(31970525,31672112);the National Key Research and Development Project of China(2019YFD1001401-GJ03);Advanced Foreign Experts Project(G2021157012L,G20200017071);Cultivating Fund Project of Hubei Hongshan Laboratory(2022hspy002);Fundamental Research Funds for the Central Universities(2662018PY099)from Chinese government;Breeding of breakthrough new citrus varieties and creation of new germplasms,Science and Technology Planning Project of Sichuan Province(2021YFYZ0023-02);Comprehensive experimental station of middle and late maturing citrus in Chengdu,China Agriculture Research System(CARS-26)。
Citrus sinensis is the most cultivated and economically valuable Citrus species in the world,whose genome has been assembled by three generation sequencings.However,chromosome recognition remains a problem due to the ...
关键词：Chromosomalmarker FISH CMA banding Genomic heterozygosity Chromosomal translocation Sweet orange 
Pinpointing the animal origins of SARS-CoV-2:a genomic approach
《Journal of Genetics and Genomics》2022年第9期900-902,共3页Shilei Zhao Yali Hou Xiaolong Zhang Alice Hughes Na Liu Minsheng Peng Qihui Wang Yongbiao Xue Hua Chen 
supported by the Key Program of Chinese Academy of Sciences(KJZD-SW-L14);the National Key R&D Program of China(Grant No.2021YFC0863400,2021YFC2301305,and 2020YFC0847000)。
Understanding the origins of zoonoses is critical to developing the means to prevent zoonotic spillover into the future.Like 60% of emerging diseases in humans(Jones et al.,2008),SARS-CoV-2 is likely to have zoonotic ...
关键词：ORIGIN PREVENTION LIKELY 
Plant pan-genomics:recent advances,new challenges,and roads ahead被引量：2
《Journal of Genetics and Genomics》2022年第9期833-846,共14页Wei Li Jianan Liu Hongyu Zhang Ze Liu Yu Wang Longsheng Xing Qiang He Huilong Du 
supported by the National Natural Science Foundation of China(32100500);the Natural Science Foundation of Hebei Province(C2021201048);Interdisciplinary Research Program of Natural Science of Hebei University。
Pan-genomics can encompass most of the genetic diversity of a species or population and has proved to be a powerful tool for studying genomic evolution and the origin and domestication of species,and for providing inf...
关键词：Plant pan-genome Genomic evolution Crop domestication Graph-based genome 
Kilobase-scale genomic deletion of DOTFL1 in Dendrobium orchids被引量：1
《Journal of Genetics and Genomics》2022年第1期81-84,共4页Yan Li Bin Zhang Hao Yu 
supported by the Singapore National Research Foundation Competitive Research Programme(NRF-CRP22-2019-0001);the intramural research support from National University of Singapore and Temasek Life Sciences Laboratory。
Orchids make up one of the largest families of flowering plants(Orchidaceae) with a variety of ecological habitats and broad economic impact for their ornamental and medicinal values in the world.Sexual hybridization ...
关键词：TRAITS HABITAT breeding 
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