National Natural Science Foundation of China(ID 82073358 to Hua Jiang,ID 82073359 to Zonghai Li,82272920 to Min Zhou);Shanghai Municipal Health and Health Commission(ID 20234Y0193 to Sun Ruixin);Shanghai Oriental Talent Youth Project(to Sun Ruixin);Shanghai“Rising Stars of Medical Talents”Youth Development Program-Clinical Laboratory Practitioner Program(ID 2023-JY to Sun Ruixin);“Gan Quan Xin Xing”talent training program of Shanghai Tongji Hospital(HRBC 2307).
Chimeric antigen receptor-expressing T(CAR-T)cells induce robust antitumor responses in patients with hematologic malignancies.However,CAR-T cells exhibit only limited efficacy against solid tumors such as hepatocellu...
supported by grants from the National Natural Science Foundation of China(Nos.82102169,82003252,82202986,82301960);Outstanding Young Talents Seedling Program of Guangdong Hospital of Traditional Chinese Medicine(No.SZ2023QN03);Young Doctor“Sailing”Project of Science and Technology Department of Guangzhou(No.2024A04J3291);Shenzhen Municipal Government of China(No.JCYJ20210324102807019).
CD39 serves as a crucial biomarker for neoantigen-specific CD8^(+)T cells and is associated with antitumor activity and exhaustion.However,the relationship between CD39 expression levels and the function of chimeric a...