supported by the National Key Research and Development Program(2022YFA1302900);Shanghai Young Excellent Academic Leader Program(20XD1424900);Shanghai Municipal Science and Technology Major Project;the National Natural Science Foundation of China(32171220,22107111,21977105);the Youth Innovation Promotion Association CAS(2022284)。
Protein–small molecule interaction is vital in regulating protein functions and controlling various cellular processes.Hydrogen deuterium exchange mass spectrometry(HDX-MS)is a powerful methodology to study protein–...
supported by the National Natural Science Foundation of China (Nos.22004074,21927805,21803013 and 21773035);the Public Welfare Fund Project of Ningbo City,China(No.202002N3113);the National Key Research and Development Program of China(No.2020YFF01014601);the K.C.Wong Magna Fund in Ningbo University,China.
In this study, the effects of lead ions(Pb^(2+)) on the conformations of leucine encephalin(LE) and methionine encephalin(ME) in gas phase were studied using hydrogen/deuterium exchange mass spectrometry(HDX-MS) and q...