目的鉴定富含亮氨酸重复蛋白15(leucine-rich repeat-containing protein-15,LRRC15)来源的优势细胞毒性T淋巴细胞(cytosolic T lymphocyte,CTL)表位肽,并验证其诱导CTL特异性抗乳腺癌免疫效应。方法收集中国医科大学附属第一医院乳腺...
目的预测、筛选及合成尤文肉瘤EWS-FLI1蛋白HLA-A2.1限制性细胞毒性T淋巴细胞(Cytotoxic T Lymphocyte,CTL)表位,初步鉴定EWS-FLI1表位肽。方法综合运用BIMAS、SYFPEITHI、Predep和IEDB方案对EWS-FLI1蛋白进行HLA-A^*0201限制性CTL...
This work was supported by the grants from the National Science Foundation of China (No. 30371598) and Shanghai Leading Academic Discipline Project (No. T0206)
HLA-A2.1-associated peptides, extracted from human melanoma cells, were used to study epitopes for melanoma-specific HLA-A2.1-restricted cytotoxic T lymphocytes (CTLs) by epitope reconstitution, active peptide seque...