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Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction被引量：4
《Cell Research》2019年第10期804-819,共16页Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte 
JSPS KAKENHI(15K21762 and 18H04036);Takeda Science Foundation;The Uehara Memorial Foundation;National Institutes of Natural Sciences(BS291007);The Sumitomo Foundation(170220);The Naito Foundation;The Kurata Grants(1350);Mochida Memorial Foundation;The Inamori Foundation.This research was supported by Guangdong Provincial Key Laboratory of Genome Read and Write(No.2017B030301011);Guangdong Provincial Academician Workstation of BGI Synthetic Genomics(No.2017B090904014);Shenzhen Peacock Plan(No.KQTD20150330171505310).J.C.I.B.was supported by The Leona M.and Harry B.Helmsley Charitable Trust(2012-PG-MED002);the G.Harold and Leila Y.Mathers Charitable Foundation;NIH(R01HL123755 and 5 DP1 DK113616);The Progeria Research Foundation;The Glenn Foundation,KAUST,The Moxie Foundation;Fundacion Dr.Pedro Guillen;AFE and Universidad Catolica San Antonio de Murcia(UCAM).
In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools...
关键词：VIVO DONOR dividing 
Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system被引量：25
《Cell Research》2015年第5期634-637,共4页Jia Li Bai-bing Zhang Yong-gang Ren Shan-ye Gu Yuan-hang Xiang Cheng Huang Jiu-lin Du 
We thank Drs Bo Zhang, Hui Yang and Filippo Del Bene for comments on the manuscript and Dr Bo Zhang for providing zCas9. This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences （XDB02040003）, the National Basic Research Program of China （973 Program; 2011CBA00400, 2012CB945101）, the National Outstanding Young Scientist Program of the National Natural Science Foundation of China （31325011）, Shanghai Subject Chief Scientist Program of the Science and Technology Commission of Shanghai （14XD1404100）, and the Postdoctoral Research Program of Shanghai Institutes for Biological Sciences （2014KIP307）.
Dear Editor, Animals carrying exogenous genes integrated at specific genomic loci are versatile tools for biological research [1]. Zebrafish （Danio rerio）, an emerging vertebrate animal model, is widely used in stu...
关键词：斑马鱼 性基因 内含子 脊椎动物模型 神经生物学 整性 介导 系统 
Targeted gene disruption by use of a group 11 intron （targetron） vector in Clostridium acetobutylicum被引量：25
《Cell Research》2007年第11期963-965,共3页Lijun Shao Shiyuan Hu Yi Yang Yang Gu Jun Chen Yunliu Yang Weihong Jiang ShengYang 
Dear Editor： Clostridium acetobutylicum, a gram-positive, anaerobic, spore-forming bacterium, is capable of using a wide variety of carbon sources to produce acetone, butanol and ethanol. To improve solvent producti...
关键词：11内含子 梭菌属 基因表达 细胞研究 
Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1
《Cell Research》2005年第6期423-429,共7页Deanna YANIW Jim HU 
This work was supported by operating grants from the Canadian Institutes of Health Research;the Canadian Cystic Fibrosis Foundation(to J.H.);the Foundation Fighting Blindness—Canada(to J.H.).
The role of Ese-2,an Ets family transcription factor,in gene regulation is not known.In this study,the interactionbetween Ese-2 and cytokeratin 18(K18)intron 1 was characterized in lung epithelial cells.Reporter gene ...
关键词：transcription factor epithelial cells cytokeratin 18 AIRWAY gene regulation. 
Increment of hFIX expression with endogenous intron 1 in vitro
《Cell Research》1997年第1期21-29,共9页ZHENG BING XIAO YUN QIU MIN TAN YONG NA XING DARU LU JING LUN XUE XIN FANG QIU(Institute of Genetics, Fudan Univerisity, Shanghai 200433) 
This paper probes into the feasibility of increasing expression level of hFIX gene with endogenous nitron 1 sequence. hFIX minigene was obtained with middle sequence truncated nitron 1 inserted into the relative site ...
关键词：Intron 1 human clotting factor IX (hFIX) gene transfer gene expression reverse inserted sequence 
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