MEDIATOR

作品数：248被引量：433H指数：10
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Redefining the modular organization of the core Mediator complex被引量：5
《Cell Research》2014年第7期796-808,共13页Xuejuan Wang Qianqian Sun Zhenrui Ding Jinhua Ji Jianye Wang Xiao Kong Jianghong Yang Gang Cai 
Acknowledgments This work was supported by the National Basic Research Program （2013CB910200 and 2014CB910700）, the National Natural Science Foundation of China （31222017）, and the Ministry of Education of PRC （NCET-11-0874）. We thank Xuefeng Zhu （University of Gothenburg, Sweden） for providing the TP 161 strain for expression of S. pombe Mediator.
The Mediator complex plays an essential role in the regulation of eukaryotic transcription. The Saccharomyces cerevisiae core Mediator comprises 21 subunits, which are organized into Head, Middle and Tail modules. Pre...
关键词：MEDIATOR modular organization nanogold labeling Head ＋ Middle modules 
Mediator redefines itself
《Cell Research》2014年第7期775-776,共2页Nicholas C Sennett Dylan J Taatjes 
Mediator is a large and structurally dynamic protein complex that is globally required for eukaryotic transcription by RNA polymerase II. In a recent paper published in Cell Research, Wang et al. report for the first ...
关键词：定义域 调解 蛋白质复合物 RNA聚合酶 全球范围 转录 真核 细胞 
microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming被引量：9
《Cell Research》2013年第1期142-156,共15页Xudong Guo Qidong Liu Guiying Wang Songcheng Zhu Longfei Gao Wujun Hong Yafang Chen Minjuan Wu Houqi Liu Cizhong Jiang Jiuhong Kang 
This work was supported by grants from the Ministry of Science and Technology （2011CB965100, 2011DFA30480, 2010CB944900, 2010CB945000, and 2011CBA01100）, the National Natural Science Foundation of China （91219305, 31071306, 31101061, 31210103905, 90919028, 31000378, 31171432, and 30971451）, the Science and Technology Commission of Shanghai Municipality （11ZR1438500 and 11XD1405300）, and the Ministry of Education （IRT1168 and 20110072110039）. The work was also supported by the ＂Chen Guang＂ project, the Shanghai Municipal Education Commission and Shanghai Education Development Foundation （12CG19） and the Fundamental Research Funds for the Central Universities.
Fibroblasts can be reprogrammed into induced pluripotent stem cells （iPSCs） by the application of Yamanaka factors （OSKM）, but the mechanisms underlying this reprogramming remain poorly understood. Here, we report...
关键词：SOX2 miR-29b DNMT rcprogramming MET Dlkl-Dio3 
The PPARγ-FGF1 axis： an unexpected mediator of adipose tissue homeostasis被引量：7
《Cell Research》2012年第10期1416-1418,共3页Kai Sun Philipp E Scherer 
Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adip...
关键词：脂肪组织 代谢平衡 PPAR 胰岛素敏感性 组织重构 细胞因子 脂肪细胞 轴 
HIF-2α - a mediator of osteoarthritis？被引量：3
《Cell Research》2010年第9期977-979,共3页Christopher L Murphy 
Two recent publications in Nature Medicine （June 2010） have focused attention on the role ofhypoxia inducible factor HIF-2α in cartilage [1, 2]. Using similar mouse models, both groups provide striking evidence imp...
关键词：缺氧诱导因子 骨关节炎 小鼠模型 出版物 医学 
A novel mediator of the amyloid-βneurotoxicity in Alzheimerls disease:Ubiquitin conjugating enzyme E2-25K/Hip-2 as upstream of caspase-12
《Cell Research》2002年第3期288-288,共1页YUHYUNSONG JOOYONGLEE 等 
Accumulation of amyloid-β(Aβ) and its neurotoxicity are regarded as a major factor promoting neu-ronal degeneration in Alzheimer's disease (AD). Upon investigation of Aβtoxicity using DNA microarray, we isolated ub...
关键词：淀粉样蛋白-β 神经毒性 早老性痴呆 介导因子 遍在蛋白结合酶 E2-25K/Hip-2 CASPASE-12 
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