云南高校图书馆联盟文献共享服务平台- DNMT

DNMT: 作品数：52被引量：119H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：樊红姜蓉王子卫汤为学范晶更多>>; 相关机构：东南大学河北医科大学天津医科大学重庆医科大学附属第一医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家现代农业产业技术体系建设项目中国博士后科学基金河南省自然科学基金更多>>

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis: 《Bone Research》2024年第4期966-979,共14页Binjia Ruan Jian Dong Fanhao Wei Zhiqiang Huang Bin Yang Lijun Zhang Chuling Li Hui Dong Wangsen Cao Hongwei Wang Yongxiang Wang; supported by the National Key Research and Development Program of China (2023YFB3810200,2023YFB3810204,2022YFF0710801);the National Natural Science Foundation of China (82470749,82370899,82272502,82072423)。; Osteoporosis(OP)is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure and pathologically involving various forms of regulated bone cell death.However,the exact role,ce...; 关键词：reversed PRESERVING exact

DNA甲基化在外周T细胞淋巴瘤中的研究进展: 《临床医学进展》2024年第8期1181-1187,共7页张向慧; 外周T细胞淋巴瘤是一组罕见的强侵袭性的非霍奇金淋巴瘤,绝大部分目前治疗效果欠佳。近些年的证据表明表观遗传失调对于PTCL的发生发展起着驱动作用,特别是DNA甲基化。已发现在PTCL中存在DNA甲基化异常以及DNA甲基化修饰酶DNMT、TET、ID...; 关键词：外周T细胞淋巴瘤 DNA甲基化发病机制 DNMT TET IDH

椰子DNMT家族基因的鉴定和生物信息学分析: 《分子植物育种》2023年第18期5967-5973,共7页卫晓宇孙秋艾夏薇陈如男肖勇; 海南省科技合作项目(ZDYF2020215)资助。; DNA甲基化(DNA methylation)能引起染色质结构、DNA结构和稳定性等的改变,影响基因的时空表达。DNA甲基转移酶(DNA methyltrans ferase, DNMT)负责催化完成DNA的甲基化。本研究通过比对已有的椰子基因组数据,找到CnDNMT家族基因,删除不...; 关键词：椰子 DNMT家族甲基化生信分析

DNA methylation in the genesis,progress and prognosis of head and neck cancer: 《Holistic Integrative Oncology》2023年第1期200-212,共13页Zijian Guo Wenwen Liu Yuhan Yang Shunhao Zhang Chunjie Li Wenbin Yang; supported by the Sichuan University-Panzhihua City 2021 Campus Cooperation Special Fund Project[grant number 2021CDPZH-7].; Epigenetic alteration studies in cancer research have been progressing rapidly in recent years.DNA methylation,including DNA hypermethylation and DNA hypomethylation,is one of the main epigenetic alterations in head a...; 关键词：Head and Neck Cancer(HNC) DNA Methylation DNA(Cytosine-5-)-Methyltransferases(DNMT) Ten-Eleven Translocation(TET) CARCINOGENESIS

家蚕DNA甲基转移酶功能预测及其在BmNPV感染下的表达特征被引量：1: 《南方农业学报》2022年第9期2665-2673,共9页张一川张永红邵榆岚白兴荣; 云南省重大科技专项(202102AE090010);云南省应用基础研究项目(2018FD127);现代农业产业技术体系建设专项(CARS-18-SYZ21)。; 【目的】明确家蚕DNA甲基转移酶基因(BmDNMT)生物信息学基本特征及其在家蚕核型多角体病毒(BmNPV)感染前后的表达情况,揭示DNA甲基化在家蚕抗病毒免疫方面的作用机制,为挖掘家蚕抗病毒标志基因和药物靶标蛋白等提供理论依据。【方法】通...; 关键词：家蚕核型多角体病毒(BmNPV) DNA甲基转移酶(DNMT) DNA甲基化药物靶标

猪DNA甲基转移酶基因家族进化分析: 《中国畜牧兽医》2022年第9期3283-3291,共9页龚文滔潘向春蔡佳丽王祎菲李加琪张哲袁晓龙; 财政部和农业农村部:国家现代农业产业技术体系。; 【目的】探究猪DNA甲基转移酶(DNMT)基因家族的基因特性及表达模式。【方法】利用生物信息学方法鉴定猪全基因组范围的DNMT基因家族,并对其染色体定位、理化性质、蛋白质结构、亚细胞定位、基因结构、保守基序、系统进化关系、共线性关...; 关键词：猪 DNA甲基转移酶(DNMT) 系统进化表达分析

Inhibiting DNA methylation alleviates cisplatininduced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway被引量：5: 《Acta Pharmaceutica Sinica B》2022年第3期1305-1321,共17页Yingzi He Zhiwei Zheng Chang Liu Wen Li Liping Zhao Guohui Nie Huawei Li; was supported by grants from the National Key R&D Program of China(No.2017YFA0103900);the National Natural Science Foundation of China(Nos.82071045,81870728,81830029,and 81970875);Shanghai Rising-Star Program(19QA1401800)。; Cisplatin-related ototoxicity is a critical side effect of chemotherapy and can lead to irreversible hearing loss.This study aimed to assess the potential effect of the DNA methyltransferase(DNMT)inhibitor RG108 on ci...; 关键词：CISPLATIN DNMT Apoptosis Hair cell Spiral ganglion neurons RG108 Mitochondrial dysfunction ROS

Design, synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual inhibitors: 《Chinese Chemical Letters》2021年第8期2479-2483,共5页Qinsheng Sun Qiuzi Dai Cunlong Zhang Yan Chen Lei Zhao Zigao Yuan Yuyang Jiang; financial supports from China Postdoctoral Science Foundation (No.2018M631825);Shenzhen Development and Reform Committee (No.2019156);Shenzhen Science,Technology and Innovation Commission (No.JCYJ20180306174248782);Department of Science and Technology of Guangdong Province (No.2017B030314083);Shenzhen Bay Laboratory Open Funding (No.SZBL2019062801009)。; DNA methyl transferase(DNMT) and histone deacetylase(HDAC) are well recognized epigenetic targets for discovery of antitumor agents.In this study,we designed and synthesized a series of nucleoside base hydroxamic acid...; 关键词：EPIGENETIC DNMT HDAC Multitarget Antitumor bioactivity

Epigenetic regulation of prostate cancer被引量：2: 《Genes & Diseases》2020年第4期606-613,共8页Ruixin Wang Xiaoqi Liu; NIH R01 CA157429(X.Liu);R01 CA192894(X.Liu);R01 CA196835(X.Liu);R01 CA196634(X.Liu);The work was also partially supported by University of Kentucky Cancer Center(P30 CA177558).; Prostate cancer is(PCa)the second leading cause of cancer death in males in the United State,with 174,650 new cases and 31,620 deaths estimated in 2019.It has been documented that epigenetic deregulation such as histo...; 关键词：DNMT EPIGENETICS EZH2 HDAC PHOSPHORYLATION Prostate cancer

DNA甲基化与膀胱癌关系的研究进展被引量：1: 《西南军医》2020年第5期424-428,共5页朱理汪翼; 衡阳市科学技术发展计划项目(项目编号:2018KJ135);湖南省教育厅重点项目(项目编号:16A188)。; 膀胱癌是最常见的泌尿系恶性肿瘤,其发病率和死亡率一直居高不下,严重威胁着人类的生命健康。DNA甲基化作为表观遗传学重要组成部分,近年来与肿瘤的关系一直是研究的热点,DNA甲基化转移酶的调节失控和CPG岛的高甲基化可导致肿瘤的发生,...; 关键词：DNA甲基化 DNMT CPG岛膀胱癌

DNMT