supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29030104);the National Natural Science Foundation of China (31870731, 31971129);the Fundamental Research Funds for the Central Universities (WK9100000001);USTC New Medicine Joint Fund Training Program(WK9110000136);China Postdoctoral Science Foundation(2020M670084ZX);Hefei Comprehensive National Science Center (BJ9100000005)。