supported by the Key Research Project of Tianjin Health Industry (No. 16KG101);Research Project of Combining Traditional Chinese and Western Medicine of Tianjin Health and Family Planning Committee (No. 2017056);the Natural Science Foundation of Tianjin Municipality (No. 18JCYBJC27500,17JCYBJC28000);2017 Youth Researchof Enhua Cup (No. TJMZJJ-2017-01) and 2018 Tianjin First Central Hospital Academy Project,China (No. CF201819)。