supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions,PAPD (No.ysxk-2010);the Open Project Program of National First-Class Key Discipline for Science of Chinese Materia Medica,Nanjing University of Chinese Medicine (No.2011ZYX2- 006);the research fund of Ministry of health of the people's republic of China (No. WKJ2010-2-019);Zhejiang Province Chinese medicine research program (No.2008ZA002);the fund of Zhejiang modernization of traditional Chinese medicine item (No.[2008]436);Science Foundation of Zhejiang Chinese Medical University (No.7211093)~~