李中杰

作品数:6被引量:12H指数:3
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供职机构:北京大学化学与分子工程学院化学生物学系更多>>
发文主题:HPLC-DAD法氧化槐果碱根茎槐果碱苦参更多>>
发文领域:医药卫生理学更多>>
发文期刊:《Journal of Chinese Pharmaceutical Sciences》《药物分析杂志》《现代医药卫生》更多>>
所获基金:国家教育部博士点基金国家自然科学基金更多>>
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Rapid screening of anti--HIV ingredients in Artemisia rupestris L. extracts interacting with V3 loop region of HIV--1 gp120 and reverse transcriptase by affinity capillary electrophoresis and capillary zone electrophoresis
《Journal of Chinese Pharmaceutical Sciences》2015年第9期625-629,共5页赵怡然 李中杰 姜勇 张晓丹 凌笑梅 
National Natural Science Foundation(Grant No.81373372);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110001110021 and 20130001110059)
HIV-1 gains entry into target cells by sequentially interacting with cellular receptors and co-receptors. Both the receptor and co-receptor are recognized by HIV-1 envelope protein gpl20, which plays a key role in the...
关键词:HIV V3 loop RIQRGPGRAFVTIGK Reverse transcriptase Affinity capillary electropiaoresis Capillary zone electrophoresis 
Interactions of carrageenan or its degradation product with R15K by affinity capillary electrophoresis
《Journal of Chinese Pharmaceutical Sciences》2015年第6期400-404,共5页李中杰 李立 王孝伟 刘俊义 凌笑梅 
National Natural Science Foundation(Grant No.81373372);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110001110021 and 20130001110059)
V3 loop of HIV-1 envelop protein gp120 plays a pivotal role in the entry process of HIV-1 into target cells. R15K, the relatively conserved region of V3 loop, can be used in binding studies instead of recombinant gp12...
关键词:HIV-1 V3 peptides ACE CARRAGEENAN Carrageenan degradation 
Study of the interactions between compound S009 and the extracellular loops of CC chemokine receptor 4 by capillary zone electrophoresis
《Journal of Chinese Pharmaceutical Sciences》2014年第3期186-189,共4页杨璐 帕子来提.亚库甫 李美娜 凌笑梅 李中杰 王应 
National Natural Science Foundation(Grant No.81072612,31270915 and 81071749);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.201 10001110021 and 20120001110001);the Open Foundation of State Key Laboratory of Natural and Biomimetic Drugs(Grant No.K20110109)
CC chemokine receptor 4(CCR4) is a G-protein-coupled receptor which plays a pivotal role in allergic inflammation. In the present study, three extracellular loops(EL1-3) of CCR4 were synthesized, and the interacti...
关键词:CCR4 CZE Compound S009 ML40 Extracellular loops 
中药三叶青有效化学成分及在临床医学上的意义被引量:4
《现代医药卫生》2013年第1期85-86,共2页何丽针 李中杰 
三叶青,学名三叶崖爬藤,为葡萄科崖爬藤属植物,主要分布于长江以南如浙江、江西、福建等省。三叶青常以块根或全草入药,具有清热解毒、祛风化痰、活血止痛的功效。在药理及临床方面具有抗肿瘤、抗病毒、退高热等显著疗效。
关键词:三叶青 药理学 中药化学成分 有效化学成分含量 
HPLC-DAD法测定自采苦参根茎和根中5个生物碱的含量被引量:4
《药物分析杂志》2012年第3期512-514,共3页张萍 杨璐 王耀欣 殷其蕾 贺锐锐 詹先王 刘勇 袁丽佳 李中杰 韩南银 
目的:测定自采苦参根茎和根中苦参碱、氧化苦参碱、槐果碱、氧化槐果碱、槐定碱的含量,以便了解采自同一株植物的苦参根茎和根中苦参碱和氧化苦参碱的总量。方法:采用Welch Materials XtimateTMC18(4.6 mm×150 mm,5μm)色谱柱,流动相A...
关键词:自采苦参 根茎  同一株植物 生物碱 苦参碱 氧化苦参碱 槐果碱 氧化槐果碱 槐定碱 中药材 高效液相色谱法 标准改善 
HPLC-DAD法测定商品苦参根茎和根中5个生物碱的含量被引量:5
《药物分析杂志》2011年第12期2294-2297,共4页张萍 杨璐 王耀欣 殷其蕾 贺锐锐 詹先王 刘勇 袁丽佳 李中杰 韩南银 
目的:测定商品苦参根茎和根中苦参碱、氧化苦参碱、槐果碱、氧化槐果碱、槐定碱的含量,主要了解苦参根茎中苦参碱和氧化苦参碱总量是否达到中国药典2010年版规定的不低于1.0%。方法:采用Welch Materials XtimateTM C18(4.6 mm×150mm,5...
关键词:苦参 根茎  生物碱 苦参碱 氧化苦参碱 槐果碱 氧化槐果碱 槐定碱 高效液相色谱法 
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