National Natural Science Foundation(Grant No.81373372);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110001110021 and 20130001110059)
HIV-1 gains entry into target cells by sequentially interacting with cellular receptors and co-receptors. Both the receptor and co-receptor are recognized by HIV-1 envelope protein gpl20, which plays a key role in the...
National Natural Science Foundation(Grant No.81373372);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110001110021 and 20130001110059)
V3 loop of HIV-1 envelop protein gp120 plays a pivotal role in the entry process of HIV-1 into target cells. R15K, the relatively conserved region of V3 loop, can be used in binding studies instead of recombinant gp12...
National Natural Science Foundation(Grant No.81072612,31270915 and 81071749);Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.201 10001110021 and 20120001110001);the Open Foundation of State Key Laboratory of Natural and Biomimetic Drugs(Grant No.K20110109)
CC chemokine receptor 4(CCR4) is a G-protein-coupled receptor which plays a pivotal role in allergic inflammation. In the present study, three extracellular loops(EL1-3) of CCR4 were synthesized, and the interacti...