This work was supported by the National Key Research and Development Program of China(No.2018YFB1004901);the Natural Science Foundation(No.LY20F020019;LQ19F020012;LQ20F020001);Basic Public Welfare Research Project(No.LGF19E050005);Major Scientific Research Project of Zhejiang Lab(No.2019MC0AD01)of Zhejiang Province,China。