supported by the National Key R&D Program of China(2019YFA0906003);the National Natural Science Foundation of China(32000989);China Postdoctoral Science Foundation Grant(2020M682911 and 2020M670051ZX);Guangdong Special Support Program(2021JC06Y578);the Shenzhen Municipal Government of China(JCYJ20200109120016553,CJGJZD20200617102403009,and RCBS20210706092256081);the Sanming Project of Shenzhen Health and Family Planning Commission(SZSM202011017);Shenzhen Institute of Synthetic Biology Scientific Research Program(ZTXM20214005);the Shenzhen High-level Hospital Construction Fund。