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Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives： Possible Therapeutics for Neurodegenerative Diseases
《Journal of Health Science》2017年第1期9-17,共9页Seisuke Mimori Toru Hosoi Masayuki Kaneko Koichiro Ozawa Tetsuto Kanzaki Akinori Nishi Yasuyuki Nomura 
The pathogenesis of neurodegenerative diseases such as Alzheimer＇s and Parkinson＇s diseases involves the aggregation of denatured and misfolded nascent proteins. Consequently, many pharmacological approaches have be...
关键词：4-Phenylbutyric acid （4-PBA） neurodegenerative diseases chemical chaperone histone deacetylase （HDAC）. 
Fluorogenic sensing of amorphous aggregates,amyloid fibers,and chaperone activity via a near-infrared aggregation-induced emission-active probe
《Aggregate》2024年第1期309-320,共12页Wei He Yuanyuan Yang Yuhui Qian Zhuoyi Chen Yongxin Zheng Wenping Zhao Chenxu Yan Zhiqian Guo Shu Quan 
Natural Science Foundation of Shanghai,Grant/Award Number:23ZR1415300;National Natural Science Foundation of China,Grant/Award Numbers:32222049,31661143021,32171269,32201043;National Key Research and Development Program of China,Grant/Award Number:2022YFF1102900;Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Municipal Education Commission,Grant/Award Number:2021Sci&Tech0328。
The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these di...
关键词：aggregation-induced emission fluorescence molecular chaperone protein aggregation 
Identification and characterization of GIP1,an Arabidopsis thaliana protein that enhances the DNA binding affinity and reduces the oligomeric state of G-box binding factors
《Cell Research》2005年第8期567-575,共9页Paul C.SEHNKE Beth J.LAUGHNER Carla R.LYERLY LINEBARGER William B.GURLEY Robert J.FERL 
This research was supported by the U S Department of Agriculture Grants 00-35304-96Ol and 98-35301-6083.
Environmental control of the alcohol dehydrogenase(Adh)and other stress response genes in plants is in part brought about by transcriptional regulation involving the G-box cis-acting DNA element and bZIP G-box Binding...
关键词：G-box binding factor interacting protein nuclear chaperone DNA binding affinity. 
Structural basis for histone H3 recognition by NASP in Arabidopsis
《Journal of Integrative Plant Biology》2022年第12期2309-2313,共5页Yanhong Liu Liu Chen Na Wang Baixing Wu Hongyu Bao Hongda Huang 
the National Key R&D Program of China(2018YFC1004500);the Natural Science Foundation of Guangdong Province(2022A1515010501);the Chinese National Natural Science Foundation(32171206 and 31800619);the Shenzhen Science and Technology Program(KQTD20190929173906742);Key Laboratory of Molecular Design for Plant Cel Factory of Guangdong Higher Education Institutes(2019KSYS006);the Shenzhen Government‘Peacock Plan’(Y01226136);the Thousand Young Talents Program。
The structural basis for histone recognition by the histone chaperone nuclear autoantigenic sperm protein(NASP)remains largely unclear.Here,we showed that Arabidopsis thaliana AtNASP is a monomer and displays robust n...
关键词：Arabidopsis NASP ASF1 crystal structure EPIGENETICS histone chaperone histone H3 
The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics
《Journal of Biosciences and Medicines》2024年第8期347-356,共10页Robert B. Raffa Joseph V. Pergolizzi Jr. 
Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis...
关键词：CHAPERONE Sigma-1 Receptor ENERGETICS THERMODYNAMICS Isothermal Titration Microcalorimetry 
Modulation of protein fate decision by small molecules:targeting molecular chaperone machinery被引量：3
《Acta Pharmaceutica Sinica B》2020年第10期1904-1925,共22页Lei Wang Xiaoli Xu Zhengyu Jiang Qidong You 
the financial support by National Natural Science Foundation of China(81773639,81773581,81872737 and 81930100);the Natural Science Foundation of Jiangsu Province(BK20190559,BK20160746 China);National Science&Technology Major Project‘Key New Drug Creation and Manufacturing Program’(Nos.2018ZX09711002 and 2017ZX09302003,China);the Priority Academic Program Development of Jiangsu Higher Education Institutions;the Fundamental Research Funds for the Central Universities of China Pharmaceutical University(2632018ZD15,China);the Double First Class Innovation Team of China Pharmaceutical University(CPU2018GY02,China);Program for Outstanding Scientific and Technological Innovation Team of Jiangsu Higher Education;the Young Elite Scientists Sponsorship Program by CAST;the Jiangsu Qing Lan Project
Modulation of protein fate decision and protein homeostasis plays a significant role in altering the protein level,which acts as an orientation to develop drugs with new mechanisms.The molecular chaperones exert signi...
关键词：Molecular chaperone Heat shock protein family Small molecule inhibitors Protein fate Protein-protein interaction 
Orf1/SpcS Chaperones ExoS for Type Three Secretion by Pseudomonas aeruginosa被引量：1
《Biomedical and Environmental Sciences》2008年第2期103-109,共7页DA-KANG SHEN LAURIANE QUENEE MARIETTE BONNET LAURIANE KUHN MADIHA DEROUAZI DANIELE LAMOTTE BERTRAND TOUSSAINT BENOIT POLACK 
This research was supported by the association "Vaincre la Mucoviscidose" of France
Objective Pseudomonas aeruginosa is a ubiquitous and opportunistic pathogen that uses the type Ⅲ secretion system （TTSS） to inject effector proteins directly into the cytosol of target cells to subvert the host cel...
关键词：Type Ⅲ secretion system Pseudomonas aeruginosa CHAPERONE 
家蚕hsp24.3基因的克隆及功能研究
《中国农业科学》2008年第12期4201-4208,共8页刘彬斌 柴春利 王先燕 黄飞飞 鲁成 
国家自然科学基金重点项目(30330460);国家“973”计划项目(2005CB121000);国家科技攻关项目(2005BA711A07)
【目的】对家蚕hsp24.3基因(Bmhsp24.3)的功能进行研究,为选育抗逆境家蚕品种提供基础材料和理论依据。【方法】在对家蚕基因组进行生物信息学分析的基础上,对家蚕低分子量热激蛋白基因Bmhsp24.3进行克隆,然后利用家蚕的芯片数据对Bmhsp...
关键词：家蚕 低分子量热激蛋白(sHSP) 分子伴侣 
Differential Expression of Molecular Chaperones in PC12 Cells Treated with PSI
《Chemical Research in Chinese Universities》2010年第4期596-603,共8页LIU Tao JIN Ying-hua ZHANG Yu CHANG Ming WANG Dan-ping HU Lin-sen 
Parkinson＇s disease（PD） is a common neurodegenerative disorder whose primary pathology features are the degeneration of dopaminergic neurons in the substantia nigra pars compacta（SNc） and the presence of eosinoph...
关键词：Ubiquitin-proteasome system（UPS） Molecular chaperone Parkinson＇s disease（PD） 
利用小干扰RNA技术在人脐静脉内皮细胞HUVEC中沉默copper chaperone for SOD1基因的研究
《华西医学》2013年第5期732-736,共5页刘俊 陈克霏 
四川大学青年教师启动基金(2011SCU11046)~~
目的采用RNA干扰技术沉默CCS(copper chaperone for SOD1)基因,构建相关小干扰RNA(siRNA),探索出针对CCS的高效siRNA序列。方法合成用于人脐静脉内皮细胞(HUVEC)细胞中沉默CCS基因的siRNA。应用脂质体转染的方法在HUVEC细胞中对CCS基因...
关键词：copper CHAPERONE for SOD 1 基因沉默 小干扰RNA 
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