Background:Calcium regulatory proteins-L-type Ca^2+ channels (LTCCs),ryanodine receptor 2 (RyR2),and Na^+/Ca^2+ exchanger isoform 1 (NCX1) have been recognized as important protective mechanisms during myoca...
Powered by the mitochondrial membrane potential,Ca2+ permeates the mitochondria via a Ca2+ channel termed Ca2+ uniporter and is pumped out by a Na+/Ca2+ exchanger,both of which are located on the inner mitochondrial m...
This study wassupported by grants from the Natural Science Foundation Project of Hubei Province (No. 2004ABA234), Wuhan Morning Program Project (No. 200850731390), and Project of Wuhan Clinical Medical Research Center in Children's Neural Disease (No. 2014-160).
Background: Na^+/Ca^2+ exchanger (NCX) plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we...