Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight  

作　　者：Chunting He Ming Qin Xun Sun 

机构地区：[1]Key Laboratory of Drug Targeting and Drug Delivery Systems,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Acta Pharmaceutica Sinica B》2020年第7期1175-1191,共17页药学学报（英文版）

基　　金：financial support of the National Natural Science Foundation of China(No.81925036);Special Funds for Prevention and Control of COVID-19 of Sichuan University(No.0082604151018,China);Zhejiang University special scientific research fund for COVID-19 prevention and control(No.2020XG2X018,China)

摘　　要：Coronaviruses(CoVs)are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Severe Acute Respiratory Syndrome(SARS)and Middle East Respiratory Syndrome(MERS).Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2)disease(COVID-19)has caused major public health crises.There have been more than 4,400,000 reported cases of COVID-2019 and more than 300,000 reported deaths to date(16/05/2020).SARS-CoV,MERSCoV and SARS-CoV-2 have attracted widespread global attention due to their high infectivity and pathogenicity.To date,there is no specific treatment proven effective against these viral infectious diseases.Vaccination is considered one of the most effective strategies to prevent viral infections.Therefore,the development of effective vaccines against highly pathogenic coronaviruses is essential.In this review,we will briefly describe coronavirus vaccine design targets,summarize recent advances in the development of coronavirus vaccines,and highlight current adjuvants for improving the efficacy of coronavirus vaccines.

关 键 词：CORONAVIRUSES SARS-COV MERS-CoV SARS-CoV-2 Vaccine ADJUVANT 

分 类 号：R392[医药卫生—免疫学]