Effect of parecoxib sodium intervention before induction on incision pain and inflammatory stress response after orthopedic surgery  

作　　者：Fu-Sheng Wei Xiu-Ze Li Peng Xu 

机构地区：[1]Anesthesiology Department,Mianyang Central Hospital in Sichuan Province,Mianyang,Sichuan Province,621000 [2]Department of Clinical Laboratory,Mianyang Central Hospital in Sichuan Province,Mianyang,Sichuan Province,621000

出　　处：《Journal of Hainan Medical University》2018年第11期27-30,共4页海南医学院学报（英文版）

摘　　要：Objective:To study the effect of parecoxib sodium intervention before induction on incision pain and inflammatory stress response after orthopedic surgery.Methods: Patients who underwent orthopedic surgery under lumbar anesthesia combined with epidural block anesthesia in Mianyang Central Hospital between March 2015 and June 2017 were selected and divided into two groups by random number table method, Par group received parecoxib sodium intervention before induction combined with routine postoperative patient-controlled intravenous analgesia, and control group only accepted routine postoperative patient-controlled intravenous analgesia. The pain neurotransmitters, inflammatory molecules and stress molecules in serum and peripheral blood were measured before surgery as well as 1 day and 3 days after surgery.Results: Compared with pain neurotransmitters of same group before surgery, serum PGE2, 5-HT, SP, NPY levels of both groups were significantly lower whereas serum COR and GH levels and peripheral blood JAK2, STAT3, IL-1, IL-6, IFIT1, Nrf2 and HO-1 mRNA expression were significantly higher 1 day and 3 days after surgery, and serum PGE2, 5-HT, SP, NPY, COR and GH levels as well as peripheral blood JAK2, STAT3, IL-1, IL-6, IFIT1, Nrf2 and HO-1 mRNA expression of Par group 1 day and 3 days after surgery were lower than those of control group.Conclusions: Parecoxib sodium intervention before induction can reduce the incision pain and inflammatory stress response after orthopedic surgery.

关 键 词：PARECOXIB SODIUM PREEMPTIVE analgesia ORTHOPEDIC surgery Pain NEUROTRANSMITTER INFLAMMATORY stress response 

分 类 号：R73[医药卫生—肿瘤]