Safety and efficacy of a novel responsive neurostimulation system in China for drug-refractory focal epilepsy:The first-in-man study  

作　　者：Kailiang Wang Yongzhi Shan Penghu Wei Liankun Ren Liang Chen Junming Zhu Guoguang Zhao 

机构地区：[1]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]International Neuroscience Institute(China-INI),Clinical Research Center for Epilepsy,Capital Medical University,Beijing 100053,China [3]China National Medical Center for Neurological Diseases,Beijing 100053,China [4]Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [5]Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai 200032,China [6]Department of Neurosurgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang 310009,China

出　　处：《Chinese Medical Journal》2024年第12期1486-1488,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82030037,81801288,and 81871009);STI2030-Major Projects(No.2021ZD0201801);the Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(No.11000022T000000444685)

摘　　要：To the Editor:Recent studies have characterized drugresistant epilepsy(DRE)as essentially a neural network disease.[1]Detection and disconnection of this pathological epileptic connectome or network can greatly improve seizure outcomes.Our team also proposes the development of the newly emerging branch of epileptic networks neurosurgery(ENN).Responsive neurostimulation(RNS)is an ENN-oriented emerging treatment option without the resection of the seizure-onset zone or epileptic focus and aims to control the seizure or other epileptic manifestations by modulating or disrupting the network’s key nodes(epileptic hubs)in a self-responsive way.

关 键 词：EPILEPSY STIMULATION DRUG 

分 类 号：R742.1[医药卫生—神经病学与精神病学]