METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children:A five-center case-control study  

作　　者：Linqing Deng Ruixi Hua Zhengtao Zhang Jinhong Zhu Jiao Zhang Jiwen Cheng Suhong Li Haixia Zhou Guochang Liu Jing He Wen Fu 

机构地区：[1]Department of Pediatric Surgery,Guangzhou Institute of Pediatrics,Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,China [2]Department of Clinical Laboratory,Biobank,Harbin Medical University Cancer Hospital,Harbin,Heilongjiang 150040,China [3]Department of Pediatric Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [4]Department of Pediatric Surgery,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an,Shaanxi 710004,China [5]Department of Pathology,Children Hospital and Women Health Center of Shanxi,Taiyuan,Shanxi 030013,China [6]Department of Haematology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325027,China

出　　处：《Chinese Medical Journal》2023年第14期1750-1752,共3页中华医学杂志（英文版）

基　　金：funded by grants from the National Natural Science Foundation of China(No:82003523);the Natural Science Foundation of Guangdong Province(No:2021A1515010860);the Science and Technology Project of Guangzhou(No:202102010170).

摘　　要：To the Editor:Wilms tumor,or nephroblastoma,is the most frequently diagnosed pediatric kidney cancer,accounting for>90%of all renal tumors in children 1–7 years old,and the disease may be related to genetic factors.^([1])As an emerging research spot,the epitranscriptome has been implicated in different RNA modifications in human diseases,including cancers.[2]Methyltransferaselike 1(METTL1),a critical RNA N7-methylguanosine(m7G)methyltransferase,can catalyze the formation of a m7G modification(mostly at nucleotide position 46 in the variable region of transfer RNAs[tRNAs])by complexing with WD repeat domain 4(WDR4).Depending on the different positions,the tRNA m7G modifications have various functions.

关 键 词：WILMS diseases KIDNEY 

分 类 号：R737.11[医药卫生—肿瘤]