Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers  

作　　者：Yuanyuan Wang Huihui Bai Meina Jiang Chengwei Zhou Zhaohui Gong 

机构地区：[1]Department of Clinical Medicine,Ningbo University School of Medicine,Ningbo,Zhejiang 315211,China [2]Department of Biochemistry and Molecular Biology,Ningbo University School of Medicine,Ningbo,Zhejiang 315211,China [3]Zhejiang Province Key Laboratory of Pathophysiology,Ningbo University School of Medicine,Ningbo,Zhejiang 315211,China [4]Department of Thoracic Surgery,The Affiliated Hospital of Ningbo University School of Medicine,Ningbo,Zhejiang 315020,China

出　　处：《Chinese Medical Journal》2023年第7期757-766,共10页中华医学杂志（英文版）

基　　金：research grants from the Major Project for Science and Technology Innovation 2025 of Ningbo(No.2019B10037);the K.C.Wong Magna Fund in Ningbo University.

摘　　要：Long non-coding RNAs(lncRNAs)reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers.The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers.Notably,JPX participates in cancer growth,metastasis,and chemoresistance,by acting as a competing endogenous RNA for microRNA,interacting with proteins,and regulating some specific signaling pathways.Moreover,JPX may serve as a potential biomarker and therapeutic target for the diagnosis,prognosis,and treatment of cancer.The present article summarizes our current understanding of the structure,expression,and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine.

关 键 词：BIOMARKER CANCER JPX Long non-coding RNA Therapeutic target 

分 类 号：R730[医药卫生—肿瘤]