一株嗜碱放线菌发酵液 中的抗肿瘤活性成分(英文)  

Antitumor Components from the Secondary Metabolites of An Alkalophilic Actinomycete

作　　者：李一青[1] 黄学石[2] 李铭刚[1] SATTLER Isabel 赵江源[1] 文孟良[1] 

机构地区：[1]云南大学教育部微生物资源开放研究重点实验室云南省生物资源保护与利用重点实验室 [2]Hans-Knll-Institute for Natural Product Research Beutenbergstraβe 11a,D-07745 Jena,Germany

出　　处：《天然产物研究与开发》2008年第2期251-253,共3页Natural Product Research and Development

基　　金：This work was supported by the National Natural Sci-ence Foundation of China (20462008);Yunnan Provincial Natural Sci-ence Foundation (2004C0002Z);German Federal Ministry for Ed-ucation Science Research and Technology (BMBF,CHN01/328)

摘　　要：从嗜碱放线菌YIM80149的发酵液中分离得到4个抗肿瘤活性成分。根据波谱数据,鉴定为4′,7-dihydroxyisoflavone (1)、4′,5,7-trihydroxyflavone (2)、3-(4-hydroxy-3-methoxyphenyl)-2(E)-propenoic acid (3)、2-methoxy-1,4-naphthoquinone (4)。Four antitumor components were isolated from the culture broth of the alkalophilic actinomycete YIM 80149.They were identified as 4′,7-dihydroxyisoflavone (1),4′,5,7-trihydroxyflavone (2),3-(4-hydroxy-3-methoxyphenyl)-2(E)-propenoic acid (3),2-methoxy-1,4-naphthoquinone (4) on the basis of the spectroscopic analysis.

关 键 词：嗜碱放线菌 抗肿瘤 ISOFLAVONE FLAVONE 2-propenoic ACID 1 4-naphthoquinone 

分 类 号：R914[医药卫生—药物化学]