Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70  

作　　者：吴卫平 匡培根 姜树军 张小澍 杨炯炯 隋南 Albert Chen 匡培梓 

机构地区：[1]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital,Postgraduate Military Medical School,Beijing 100853 [2]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital,Postgraduate Military Medical School Beijing 100853 [3]Neurotransmitter Research Laboratory,Department of Neurology,Chinese PLA General Hospital Postgraduate Military Medical School,Beijing 100853 [4]PLA 261 Hospital,Beijing 100094 [5]Institute of Psychology,Chinese Academy of Sciences,Beijing 100101

出　　处：《Journal of Traditional Chinese Medicine》2000年第4期297-301,共5页中医杂志（英文版）

摘　　要：　　The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of HSP32 and HSP70 immune reactive cells of Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of HSP32 and HSP70 is probably related to the attenuation of ischemic injury.　　The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats in searching a goal were significantly longer than those of the sham-operated rats and at the same time HSP32 and HSP70 expression of left temporal ischemic region in rats was significantly increased as compared with the sham-operated rats. However, the mean reaction time and distance of the Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of HSP32 and HSP70 immune reactive cells of Batroxobin-treated rats was also less than that of the ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats; and the down-regulation of the expression of HSP32 and HSP70 is probably related to the attenuation of ischemic injury.

关 键 词：OXYGENASES Animals BATROXOBIN Brain Ischemia DOWN-REGULATION HSP70 Heat-Shock Proteins Heat-Shock Proteins Heme Oxygenase (Decyclizing) Learning Disorders Male Maze Learning Memory Disorders Random Allocation RATS Rats  Wistar Snake Venoms Spatial Behavior Temporal Lobe 

分 类 号：R749.1[医药卫生—神经病学与精神病学]