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DOWN-REGULATION: 作品数：197被引量：787H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：邹冬玲高昌俊刘君王冬孙绪德更多>>; 相关机构：中山大学南京医科大学福建医科大学第四军医大学唐都医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金广东省自然科学基金更多>>

Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation: 《Genes & Diseases》2025年第2期414-424,共11页Ye Zhu Xuehuan Meng Qiming Zhai Liangjing Xin Hao Tan Xinyi He Xiang Li Guoyin Yang Jinlin Song Leilei Zheng; supported by the Natural Science Foundation of China (No.82471016,81470772);Chongqing Talent Program:Innovative Leading Talents (Medical Field,No.CQYC20210303384);Chongqing Medical Scientific Research Project (China) (No.cstc2020jcyj-msxmX0307);Youth Innovation in Future Medicine (Chongqing Medical University) (No.W0033).; Orthodontic tooth movement(OTM)depends on periodontal ligament cells(PDLCs),which sense biomechanical stimuli and initiate alveolar bone remodeling.Light(optimal)forces accelerate OTM,whereas heavy forces decelerate i...; 关键词：BIOMECHANICS Bone remodeling/regeneration MECHANO-TRANSDUCTION Orthodontic tooth movement Periodontal ligament

Material basis revelation of anti-hepatoma effect of Huachansu(Cinobufacini)through down-regulation of thymidylate synthase: 《Chinese Herbal Medicines》2025年第1期127-138,共12页Qi Wu Qimei Chen Jingyi Yang Jiayu Zhang Ailin Yang; financially supported by National Natural Science Foundation of China Grant(No.82204693);Taishan scholar engineering youth expert program of Shandong Province(No.tsqn202103110);Young and Creative Team for Talent Introduction of Shandong Province(No.10073004);Binzhou Medical University Scientific Research Fund for High-level Talents(NO.BY2020KYQD13,2019KYQD06);Standard study on Chinese medicinal materials and Decoction pieces in Shandong Province(No.2020-201)。; Objective:Hepatocellular carcinoma(HCC)is a leading cause of mortality worldwide.Huachansu(Cinobufacini)is active extract isolated from the dry skin of Bufo Bufo gargarizans.It has now been widely used in clinical tre...; 关键词：DNA damage hepatocellular carcinoma Huachansu(Cinobufacini) material basis thymidylate synthase proteasomal degradation

Down-regulation of SEIPIN transcription attenuated the triacylglycerol accumulation in Nannochloropsis oceanica: 《Journal of Oceanology and Limnology》2025年第1期187-195,共9页Lixian LIU Li GUO Hang LIU Xiaohui PAN Yanan ZONG Leili FENG Guanpin YANG; Supported by the National Key R&D Program of China(No.2022YFF1102300);the Key R&D Program of Shandong Province,China(No.2022LZGC004);the National Natural Science Foundation of China(No.32102757);the Science&Technology Innovation Project of Laoshan Laboratory(No.LSKJ202203205);the Fundamental Research Funds for the Central Universities(No.202262001)。; Abnormal content of protein SEIPIN causes Berardinelli-Seip congenital lipodystrophy type 2(BSCL2)in humans.Previous studies have shown that Arabidopsis thaliana has evolved three SEIPIN homologs,determining the fusio...; 关键词：Nannochloropsis oceanica antisense RNA SEIPIN neutral lipid

Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling: 《World Journal of Hepatology》2025年第2期159-169,共11页Zhen-Yu Xu Jia-Shi Gao Ying He Xin-Qiang Xiao Guo-Zhong Gong Min Zhang; Supported by National Natural Science Foundation of China,Key Project,No.82430071;The Scientific Research Program of FuRong Laboratory,No.2023SK2108;Clinical Medical Research Center for Viral Hepatitis of Hunan Province,No.2023SK4009;Hunan Provincial Natural Science Foundation,No.2023JJ60440;Hunan Provincial Health Commission Research Program,No.C202303088786.; BACKGROUND Hepatitis B virus(HBV)evades the innate immunity and leads to persistent chronic infection,but the molecular mechanism is still not well known.AIM To investigate whether HBV-miR-3 is involved in HBV immune ...; 关键词：Hepatitis B virus HBV-miR-3 cGAS Sting IFN-Β

Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression: 《Genes & Diseases》2024年第5期456-469,共14页Lixin Liang Tian Cai Xiaojia Li Jianhong An Sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He Keping Xie Tingting Jiang; Guangzhou Ruiqian Biotech Company(China)(No.20230330 to TJ);the National Natural Science Foundation of China(No.82072632);Guangzhou Municipality Bureau of Science and Technology,Guangzhou,China(No.202102010033);the Natural Science Foundation of Guangdong Province,China(No.2022A1515012585 to KX).; Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and progression.The molecular mechanisms underlying its dysregulation remain unclear.We identif...; 关键词：FOXM1 Gene expression Gene regulation MICRORNA Pancreatic cancer Targeted therapy

Effect of Down-regulation of MMP-2 by Quercetin on the Migration and Invasion of Uterine Fibroids Cells through the cAMP Signaling Pathway: 《Chinese Journal of Biomedical Engineering(English Edition)》2024年第2期54-61,共8页LIN Shu-ping ZOU Xiao-fen; Objective:To investigate the effect of down-regulation of matrix metalloproteinase-2(MMP-2)by down-regulating the cyclic adenosine monophosphate(cAMP)signaling pathway on the migration and invasion of uterine fibroids...; 关键词：uterine fibroids LETROZOLE cAMP signaling pathway MMP-2 cell migration and invasion

LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus被引量：1: 《Zoological Research》2024年第1期25-35,共11页Xian-Hui Ning Bing Han Ye Peng Shao-Wu Yin; supported by the National Natural Science Foundation of China(42006082);Natural Science Foundation of Jiangsu Province of China(BK20221323);“JBGS”Project of Seed Industry Revitalization in Jiangsu Province(JBGS[2021]034);State Key Laboratory of Developmental Biology of Freshwater Fish(2021KF009)。; Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)crosstalk.Despite their recognized significance i...; 关键词：LncRNA SARM miRNA ceRNA Antibacterial response

Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster: 《Genes & Diseases》2023年第6期2248-2251,共4页Sung Yeon Park Jieun Seo Seulbee Lee Joohyung Kim Sang Jeong Kim Seungbok Lee Yang-Sook Chun; supported by the National Research Foundation grants from the Korean government(No.2016R1D1A1A02937353,2018R1D1A1B07042756,2018R1A5A2025964,2019R1A2C2083886,2021R1I1A1A01044744);Jieun Seo and Seulbee Lee received a scholarship from the BK21-plus education program of the National Research Foundation of Korea.; Tauopathies,such as Alzheimer's disease(AD),are neurodegenerative diseases characterized by the deposition of neurofibrillary tangles comprising hyperphosphorylated tau protein in the human brain.1 Given that abnormal...; 关键词：TAU alterations DEGENERATION

Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts,and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss被引量：1: 《Acta Biochimica et Biophysica Sinica》2023年第11期1847-1850,共4页Yan Gu Ning Song Wen-Wen Gu Linghan Chen Xuan Zhang Jian Wang; supported by the grant from the Natural Science Foundation of Shanghai (No.23ZR1457000).; Recurrent miscarriage(RM)is defined as two or more consecutive pregnancy losses before 24 weeks of human pregnancy[1].The incidence of RM in pregnant women is 1%‒2%[2],and the RM causes in 50%of cases remain unknown[3...; 关键词：pregnancy INVASION arrangement

Effect of down-regulation of let-7c/g on triggering a double-negative feedback loop and promoting restenosis被引量：1: 《Chinese Medical Journal》2023年第20期2484-2495,共12页Qian Zhang Xiaojun Zhou Xianzhi Li Shuai Yao Shan Jiang Rui Zhang Zhiwei Zou Lin Liao Jianjun Dong; supported by the National Natural Science Foundation of China Grants(Nos.82100891,81670757,82270888,82170824,81770822,81800732,and 81900685);Natural Science Foundation of Shandong Province(No.ZR2017LH025);Shandong Provincial Medicine and Health Science and Technology Development Program(No.2017WS461);China Postdoctoral Science Foundation(No.2021M691957).; Background:Excessive proliferation and migration of vascular smooth muscle cells(VSMCs)are the main causes of restenosis(RS)in diabetic lower extremity arterial disease(LEAD).However,the relevant pathogenic mechanisms...; 关键词：RESTENOSIS Lower extremity arterial disease Vascular smooth muscle cells LET-7 Lin28a

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