OXYGENASES

作品数：9被引量：35H指数：3
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Oxidative modification of free-standing amino acids by Fe(Ⅱ)/αKG-dependent oxygenases
《Engineering Microbiology》2023年第1期56-64,共9页Hui Tao Ikuro Abe 
supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology,Japan(JSPS KAKENHI Grant No.JP16H06443,JP20KK013,and JP20H00490);Japan Science and Technology Agency(JST SICORP Grant No.JPMJSC1701);the New Energy and Industrial Technology Development Organization(NEDO,Grant No.JPNP20011);Japan Agency for Medical Research and Development(AMED)(Grant No.JP21ak0101164);H.T.is a recipient of the JSPS Postdoctoral Fellowship for Foreign Researchers(ID No.P18404).
Fe(Ⅱ)/α-ketoglutarate(αKG)-dependent oxygenases catalyze the oxidative modification of various molecules,from DNA,RNA,and proteins to primary and secondary metabolites.They also catalyze a variety of biochemical re...
关键词：Fe(II)/αKG-dependent oxygenases Amino acids Enzyme 
Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status inβ-carotene 9',10'-oxygenase knockout mice被引量：1
《Hepatobiliary Surgery and Nutrition》2022年第2期188-198,共11页Chun Liu Bruna Paola M.Rafacho Xiang-Dong Wang 
supported by grants from NIFA/AFRI(2017-67017-26363);USDA/ARS(58-1950-0074S).
Background:β-cryptoxanthin(BCX),one of the major carotenoids detected in human circulation,can protect against the development of fatty liver disease.BCX can be metabolized throughβ-carotene-15,15'-oxygenase(BCO1)an...
关键词：β-cryptoxanthin(BCX) OXYGENASES fatty liver 
AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases被引量：3
《Acta Pharmaceutica Sinica B》2021年第7期1931-1946,共16页Qingqing Dai Yuhang Yan Xiangli Ning Gen Li Junlin Yu Ji Deng Lingling Yang Guo-Bo Li 
supported by the funds from the National Natural Science Foundation of China(81874291,82073698,and 81502989);the Sichuan Science and Technology Program(2018HH0100,China);111 project(B18035,China);Outstanding Interdiscipline Project of West China Hospital of Sichuan University(ZYJC18024,China)
We herein describe AncPhore,a versatile tool for drug discovery,which is characterized by pharmacophore feature analysis and anchor pharmacophore(i.e.,most important pharmacophore features)steered molecular fitting an...
关键词：Anchor pharmacophore METALLOENZYME Virtual screening Metallo-b-lactamase Indoleamine 2 3-dioxygenase Tryptophan 2 3-dioxygenase 
Structure-guided analysis of Arabidopsis JASMONATE-INDUCED OXYGENASE(JOX)2 reveals key residues for recognition of jasmonic acid substrate by plant JOXs被引量：5
《Molecular Plant》2021年第5期820-828,共9页Xin Zhang Dongli Wang Joyce Elberse Linlu Qi Wei Shi You-Liang Peng Robert C.Schuurink Guido Van den Ackerveken Junfeng Liu 
supported by grants from the National Key Research and Development Program of China(grant no.2016YFD0300700);the National Natural Science Foundation of China(youth grant,no.32000859);the Project for Extramural Scientists of the State Key Laboratory of Agrobiotechnology(project ID:2020SKLAB6-26);The research of R.S.and G.V.d.A.was financed in part by grants from the Dutch Research Council(NWO).
The jasmonic acid(JA)signaling pathway is used by plants to control wound responses.The persistent accumulation of JA inhibits plant growth,and the hydroxylation of JA to 12-hydroxy-JA by JASMONATE-INDUCED OXYGENASEs(...
关键词：crystal structure JASMONATE-INDUCED OXYGENASEs(JOXs) jasmonic acid(JA) 12-OH-JA HYDROXYLATION 
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types:implications for cell cycle regulation and cell adhesion maintenance被引量：4
《Cancer Communications》2019年第1期214-227,共14页Wai Hoong Chang Donall Forde Alvina G.Lai 
Background: Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have significant implications for prognosis. In thi...
关键词：Oxygen-sensing gene 2-Oxoglutarate-dependent oxygenase Pan-cancer Prognosis Hypoxia KDM8 HNF4A 
The functional differentiation of the post-PKS tailoring oxygenases contributed to the chemical diversities of atypical angucyclines被引量：1
《Synthetic and Systems Biotechnology》2018年第4期275-282,共8页Keqiang Fan Qian Zhang 
National Natural Science Foundation of China(Grants:31670800,31470176,and 31130001);Ministry of Science and Technology of China(Grants:2014CB910400).
Angucyclines are one of the largest families of aromatic polyketides with various chemical structures and bioactivities.Decades of studies have made it easy for us to depict the picture of their early biosynthetic pat...
关键词：Angucycline Biosynthesis OXYGENASE FAD-dependent MONOOXYGENASE Ring opening oxygenase 
Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases被引量：1
《Protein & Cell》2015年第1期55-67,共13页Cheniun Jia Mei Li Jianjun Li Jingjing Zhang Hongmei Zhang Peng Cao Xiaowei Pan Xuefeng LU Wenrui Chang 
We would like to thank Yi Han and Shengquan Liu at the Institute of Biophysics, CAS and the staffs at Shanghai Synchrotron Radiation Facility and Photo Factory, Japan, respectively, for help during X-ray data collection. We also thank Wei Shao at Beijing Center for Physical and Chemical Analysis for help with the GC analysis, Zhen Xue at Institute of Botany, CAS for providing help for the GC-QqQ- MS/MS analysis, and Hongzhi Zhang at Institute of Geographic Sciences and Natural Resources Research, CAS for technical support with the metal content analysis by ICP-OES. This work was supported by the National Basic Research Program （973 Program） （Nos. 2011CBA00902 and 2011CBA00907）, Strategic Priority Research Program of the Chinese Academy of Sciences （XDB08020302）, National Natural Science Foundation of China（Grant Nos. 31021062 and 31170765）, and CAS Cross and Coop- eration Team for Scientific Innovation （Y31102110A）.
The fatty alk（a/e）ne biosynthesis pathway found in cyanobacteria gained tremendous attention in recent years as a promising alternative approach for biofuel production. Cyanobacterial aldehyde-deformylating oxygena...
关键词：aldehyde-deformylating oxygenase di-ironcenter crystal structure catalytic mechanism alk（a/e）neproduction 
Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury被引量：17
《World Journal of Hepatology》2013年第10期541-549,共9页Clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara 
Supported by Brazilian Foundation-FAPESP(Fundao deapoio à pesquisa do Estado de So Paulo),No.07/07139-3,10/02024-6 and CNPq
The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catab...
关键词：HEME OXYGENASES BILIRUBIN Hepatitis C KUPFFER cells POLYMORPHISMS Immunoregulatory Hypoxia Liver ISCHEMIA 
Effects of Batroxobin on Spatial Learning and Memory Disorder of Rats with Temporal Ischemia and the Expression of HSP32 and HSP70被引量：3
《Journal of Traditional Chinese Medicine》2000年第4期297-301,共5页吴卫平 匡培根 姜树军 张小澍 杨炯炯 隋南 Albert Chen 匡培梓 
　　The effect of Batroxobin on spatial memory disorder of left temporal ischemic rats and the expression of HSP32 and HSP70 were investigated with Morri`s water maze and immunohistochemistry methods. The results show...
关键词：OXYGENASES Animals BATROXOBIN Brain Ischemia DOWN-REGULATION HSP70 Heat-Shock Proteins Heat-Shock Proteins Heme Oxygenase (Decyclizing) Learning Disorders Male Maze Learning Memory Disorders Random Allocation RATS Rats  Wistar Snake Venoms Spatial Behavior Temporal Lobe 
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