OXYGENASE

作品数：136被引量：457H指数：10
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Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction
《Cancer Communications》2024年第11期1261-1286,共26页Yongcan Liu Shanchun Chen Xueying Wan Rui Wang Haojun Luo Chao Chang Peijin Dai Yubi Gan Yuetong Guo Yixuan Hou Yan Sun Yong Teng Xiaojiang Cui Manran Liu 
supported by National Key Projects of Ministry of Science and Technology of China(MOST 2018YFE0113700);National Natural Science Foundation of China(NSFC82173155,NSFC81874199);the Outstanding Professorship Program of Chongqing Medical University(2019-R10005)to Manran Liu;supported by the Outstanding Postgraduate Fund of Chongqing Medical University(BJRC202021,BJRC202025);the Chongqing Graduate Research and Innovation Project of the Chongqing Education Committee(CYB22218)for Shanchun Chen.
Background:Tumor metastasis is a major threat to cancer patient survival.The organ-specific niche plays a pivotal role in tumor organotropic metas-tasis.Fibroblasts serve as a vital component of the metastatic microen...
关键词：Matrix fibroblasts Lung metastasis Tryptophan 2 3-dioxygenase T cell dysfunction Ferropto-sis 
Phanerozoic co-evolution of O_(2)-CO_(2) and ocean habitability被引量：1
《National Science Review》2024年第6期11-14,共4页Zunli Lu Rosalind E.M.Rickaby Jonathan L.Payne Ashley N.Prow 
supported by the National Science Foundation(EAR 2121445 to Z.L.and EAR 2121392 to J.L.P.);the Natural Environment Research Council(NERC,PUCCA Project,NE/V011049/1 to R.E.M.R);the European Research Council,SCOOBI Project,(101019146 to R.E.M.R.)。
Atmospheric carbon dioxide and oxygen concentrations are partially linked via the geological cycle of organic carbon(Fig.1A–C;e.g.CO_(2)+H_(2)O↔CH_(2)O+O_(2)).The history of these two biologically active components,c...
关键词：carboxylase/oxygenase dioxide carbon 
Chlorophyllide-a Oxygenase 1(OsCAO1) Over-Expression Affects Rice Photosynthetic Rate and Grain Yield被引量：1
《Rice science》2023年第2期87-91,I0002-I0006,共10页HU Ping MA Jie KANG Shujing LI Sanfeng WU Xianmei ZENG Longjun LU Caolin HE Rui HE Huiying SHANG Lianguang RAO Yuchun ZHU Xudong XIONG Guosheng QIAN Qian GUO Longbiao WANG Yuexing 
supported by the Shenzhen Science and Technology Program,China(Grant No.KQTD2016113010482651);Natural Science Foundation of Zhejiang Province in China(Grant No.LR20C130001);Hainan Yazhou Bay Seed Laboratory,China(Grant No.B21HJ0219)。
Leaf color and photosynthesis are important factors for rice growth and development.Hence,improving the photosynthetic rate is an effective approach for increasing rice yield.We isolated a gene,chlorophyllide-a oxygen...
关键词：OsCAO1 development Oxygen 
Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder被引量：1
《World Journal of Psychiatry》2023年第4期141-148,共8页Abdulla A-B Badawy Shazia Dawood Samina Bano 
Serotonin deficiency in major depressive disorder(MDD)has formed the basis of antidepressant drug development and was originally attributed to induction of the major tryptophan(Trp)-degrading enzyme,liver Trp 2,3-diox...
关键词：Major depressive disorder Indoleamine 2 3-dioxygenase Kynurenine monooxygenase Proinflammatory cytokines Serotonin deficiency Tryptophan 2 3-dioxygenase 
Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status inβ-carotene 9',10'-oxygenase knockout mice被引量：1
《Hepatobiliary Surgery and Nutrition》2022年第2期188-198,共11页Chun Liu Bruna Paola M.Rafacho Xiang-Dong Wang 
supported by grants from NIFA/AFRI(2017-67017-26363);USDA/ARS(58-1950-0074S).
Background:β-cryptoxanthin(BCX),one of the major carotenoids detected in human circulation,can protect against the development of fatty liver disease.BCX can be metabolized throughβ-carotene-15,15'-oxygenase(BCO1)an...
关键词：β-cryptoxanthin(BCX) OXYGENASES fatty liver 
In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2’-aminocyclopropyl)alanine biosynthesis
《Engineering Microbiology》2022年第1期35-38,共4页Linlin Pang Weijing Niu Yuwei Duan Liujie Huo Aiying Li Jiequn Wu Youming Zhang Xiaoying Bian Guannan Zhong 
supported by the National Key R&D Program of China(2019YFA0905700);the National Natural Science Foundation of China(21907057,32070060);the Shan-dong Provincial Natural Science Foundation,China(ZR2019JQ11,ZR2019ZD18);the Natural Science Foundation of Jiangsu Province,China(BK20190201);the 111 project(B16030),the Youth Interdisci-plinary Innovative Research Group(2020QNQT009);the Future Plan for Young Scholars,and the Fundamental Research Funds(2019GN032)of Shandong University.
In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine((3-Acp)Ala)and 3-(trans-2’-nitrocyclopropyl)alanine((3-Ncp)Ala)are originated via two homologous proteins,BelK an...
关键词：Nitro-forming oxygenase HDO superfamily protein Belactosin A Hormaomycin Cyclopropyl ring 
Indoleamine 2,3-dioxygenase adjusts neutrophils recruitment and chemotaxis in Aspergillus fumigatus keratitis被引量：1
《International Journal of Ophthalmology(English edition)》2022年第3期380-387,共8页Shu-Xuan Guo Nan Jiang Li Zhang Wei Jiang Jing-Jing Ma 
Supported by the National Natural Science Foundation of China (No.81870632);the Youth National Natural Science Foundation of China (No.81700800);the Natural Science Foundation of Shandong Province (No.ZR2017MH008)。
AIM: To explore the effect of indoleamine 2,3-dioxygenase(IDO) on recruitment and chemotaxis function of neutrophils in Aspergillus fumigatus(A.fumigatus) keratitis.METHODS: C57BL/6 mice models of A.fumigatus keratiti...
关键词：indoleamine 2 3-dioxygenase KERATITIS NEUTROPHILS Aspergillus fumigatus innate immune 
Distribution characteristics and diversities of cbb and coxL genes in paddy soil profiles from southern China被引量：2
《Pedosphere》2021年第6期954-963,共10页Wentao PENG Yan WANG Xiuxiu ZHU Liufeng XU Juan ZHAO Zhongli CUI Hui CAO 
supported by the National Natural Science Foundation of China(Nos.42077026 and 41371262)。
The Calvin-Benson-Bassham cycle and Wood-Ljungdahl pathway are two well-known ones in the six carbon sequestration pathways,but the current knowledge of their occurrence in different layers of agricultural soil profil...
关键词：Calvin-Benson-Bassham cycle carbon dioxide fixation carbon monoxide dehydrogenase ribulose-1 5-bisphosphate carboxylase/oxygenase 
Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway被引量：10
《Acta Pharmaceutica Sinica B》2021年第9期2835-2849,共15页Yumiao Zhao Jiaxin Sun Yin Li Xiuman Zhou Wenjie Zhai Yahong Wu Guanyu Chen Shanshan Gou Xinghua Sui Wenshan Zhao Lu Qiu Yongjie Yao Yixuan Sun Chunxia Chen Yuanming Qi Yanfeng Gao 
supported by the National Natural Science Foundation of China(Nos.U1604286,81822043,and 81901687);Shenzhen Science and Technology Program(3000531,China);the Key Incubation Fund of SYSU(19ykzd29,China)
Tryptophan 2,3-dioxygnease 2(TDO2) is specific for metabolizing tryptophan to kynurenine(KYN),which plays a critical role in mediating immune escape of cancer.Although accumulating evidence demonstrates that TDO2 over...
关键词：Tryptophan 2 3-dioxygenase 2 M2 macrophage Esophageal squamous cell carcinoma IL-8 KYN 
Structure-guided analysis of Arabidopsis JASMONATE-INDUCED OXYGENASE(JOX)2 reveals key residues for recognition of jasmonic acid substrate by plant JOXs被引量：5
《Molecular Plant》2021年第5期820-828,共9页Xin Zhang Dongli Wang Joyce Elberse Linlu Qi Wei Shi You-Liang Peng Robert C.Schuurink Guido Van den Ackerveken Junfeng Liu 
supported by grants from the National Key Research and Development Program of China(grant no.2016YFD0300700);the National Natural Science Foundation of China(youth grant,no.32000859);the Project for Extramural Scientists of the State Key Laboratory of Agrobiotechnology(project ID:2020SKLAB6-26);The research of R.S.and G.V.d.A.was financed in part by grants from the Dutch Research Council(NWO).
The jasmonic acid(JA)signaling pathway is used by plants to control wound responses.The persistent accumulation of JA inhibits plant growth,and the hydroxylation of JA to 12-hydroxy-JA by JASMONATE-INDUCED OXYGENASEs(...
关键词：crystal structure JASMONATE-INDUCED OXYGENASEs(JOXs) jasmonic acid(JA) 12-OH-JA HYDROXYLATION 
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