Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats  

作　　者：Ji Yao Wang Qi Sheng Zhang Ji Sheng Guo Mei Yu Hu Department of Gastroenterology, Zhongshan Hospital, Medical Center, Fu Dan University Shanghai Medical University), Shanghai 200032, China 

出　　处：《World Journal of Gastroenterology》2001年第1期115-119,共5页世界胃肠病学杂志（英文版）

基　　金：Project supported by the National Natural Science Foundation of China, No. 39500138

摘　　要：INTRODUCTIONLiver fibrosis is a dynamic course leading tocirrhosis from a various chronic liver diseases. Thepathological basis of fibrosis is the disturbance ofproduction and degradation of the extracellularmatrix (ECM), which causes accumulation of ECMin the liver[1,2].

关 键 词：Administration  Topical Animals Anti-Inflammatory Agents Carbon Tetrachloride Cell Division Collagen Type I Collagen Type III COLLAGENASES Disease Models  Animal Gene Expression Glycyrrhetinic Acid Liver Cirrhosis Plasmids PROCOLLAGEN PROLINE RNA  Messenger RATS Rats  Sprague-Dawley Research Support  Non-U.S. Gov't THYMIDINE Tritium 

分 类 号：R575.2[医药卫生—消化系统]