云南高校图书馆联盟文献共享服务平台- THYMIDINE

THYMIDINE: 作品数：67被引量：69H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：黄韶玲邵国祥詹立张浩吴德生更多>>; 相关机构：华中科技大学湖南医科大学中国石油天然气集团公司四川大学华西医院更多>>; 相关期刊：《Genes & Diseases》《癌症》《Open Journal of Marine Science》《Cellular & Molecular Immunology》更多>>; 相关基金：国家自然科学基金卫生部临床学科重点项目国家重点基础研究发展计划福建省自然科学基金更多>>

DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug被引量：2: 《Genes & Diseases》2023年第6期2557-2571,共15页Bingxue Yang Xinran Xie Zhaoyu Wu Dazhao Lv Jiajun Hu Yuyun Chen Jiaxing Li Shuyue Luo Jiacheng Li Jie Luo Shiyi Zhang; supported by the Youth Thousand Talents Program of China,start-up grants from the Shanghai Jiao Tong University(No.WF220408211);supported by grants from the State Key Laboratory of Oncogenes and Related Genes(No.90-17-02)at Shanghai Jiao Tong University;from the Interdisciplinary Program of Shanghai Jiao Tong University(China)(No.YG2017MS18).; Hand-foot syndrome(HFS)is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes.Even though the cause and pathophysio...; 关键词：Cellular senescence cGAS-STING Cutaneous toxicity DNA damage FLUOROPYRIMIDINE Hand-foot syndrome KERATINOCYTES Thymidine prodrug

DFT-Based Chemical Reactivity Descriptors, Pharmacokinetics and Molecular Docking Studies of Thymidine Derivatives: 《Computational Chemistry》2023年第4期81-103,共23页Mohammad Ahad Hossain Shahin Sultana Mohammad Mazherul Islam Sonia Akhter Faria Nur Fatima Majabin Kantom Islam Kazi Jawad Hossain Yasuhiro Ozeki Sarkar M. A. Kawsar; Thymidine-containing derivatives are considered to be among the most significant derivatives in medicinal chemistry. In this study, we employed a combined computational approach involving density-functional theory (DF...; 关键词：THYMIDINE DFT Molecular Docking PHARMACOKINETICS Candida albicans

Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity: 《Cellular & Molecular Immunology》2022年第5期619-633,共15页Buqing Ye Liuliu Yang Benyu Liu Nian Liu Dongdong Fan Huimu Li Lei Sun Ying Du Shuo Wang Yong Tian Zusen Fan; supported by the National Key R&D Program of China (2020YFA0803501,2019YFA0508501,2021YFF0702802);the National Natural Science Foundation of China (82130088,31930036,81921003,31871494,92042302,91940305,32070533,81772646);the Beijing Natural Science Foundation (5192018);the Biological Resources Program of Chinese Academy of Sciences (KFJ-BRP-017);the Strategic Priority Research Programs of the Chinese Academy of Sciences (XDB19030203).; Neutrophils are derived from bone marrow hematopoietic stem cells(HSCs)and are the largest population among circulating white blood cells in humans,acting as the first line of defense against invading pathogens.Whethe...; 关键词：FIBROBLASTS NEUTROPHILS THYMIDINE TRANSDIFFERENTIATION Tet3

茶树Gro/Tup1基因家族鉴定及外源激素和非生物胁迫下表达分析: 《生物技术通报》2021年第12期1-12,共12页詹冬梅朱晨周承哲黄雪婷赖钟雄郭玉琼; 福建农林大学“双一流”建设科技创新能力提升培育计划(KSYLP004);6.18协同创新院茶产业技术分院专项(K1520001A);福建农林大学茶产业链科技创新与服务体系建设项目(K1520005A01);福建省高原学科建设经费(102/71201801101);福建农林大学科技创新专项基金项目(CXZX2017537)。; 明确Groucho/Thymidine uptake 1(Gro/Tup1)辅转录调控因子在茶树基因组中的数量、结构及其在非生物胁迫和外源激素处理下表达差异,为揭示Gro/Tup1在茶树激素信号转导途径及其在茶树逆境胁迫中的作用奠定理论基础。对茶树Gro/Tup1家族...; 关键词：茶树 Groucho/Thymidine uptake 1(Gro/Tup1)家族植物激素非生物胁迫

Protective autophagy by thymidine causes resistance to rapamycin in colorectal cancer cells in vitro被引量：2: 《Cancer Drug Resistance》2021年第3期719-727,共9页I.V.Bijnsdorp Godefridus J.Peters; Aim:Thynidine phosphorylase(TP)acts as a proangiogenic growth factor which may regulate mammalian Target of Rapamycin(mTOR).We investigated whether the TP substrate thymidine and overexpression of TP affected mTOR sig...; 关键词：Thymidine phosphorylase MTOR RAPAMYCIN THYMIDINE thymidine phosphorylase inhibitor AUTOPHAGY

The practical value of serum TK1 concentration expression in clinical research of malignant tumors: 《TMR Cancer》2020年第3期112-118,共7页Qiang Lv Yuan-Hong Zhao Yu Lu Rui-Xue Yang Yuan-Tao Zhong Jie Wang Zhi-Li Zhao Long Zhang; Objective:To investigate the expression of serum thymidine kinase 1(TK1)in malignant tumors and its relationship with common tumor markers.Methods:195 cancer patients in the First Teaching Hospital of Tianjin Universi...; 关键词：SERUM THYMIDINE kinase 1 TUMOR marker TUMOR Clinical DIGESTIVE system

TK1 Membrane Expression May Play a Role in the Invasion Potential of A549 Lung Cancer Cells: 《Journal of Cancer Therapy》2018年第8期605-612,共8页Evita G. Weagel Juan Mejía Roman Kovtun Joshua Keller Juan A. Arroyo Richard A. Robison Kim O’Neill; Thymidine kinase 1 (TK1) is a well-studied cancer biomarker. It is commonly found upregulated in the serum of cancer patients, and its levels correlate with stage and grade, disease progression, and prognosis. It has ...; 关键词：THYMIDINE KINASE 1 INVASION EMT

Expression and Clinical Significance of Cytokeratin-19 and Thymidine Kinase-1 in Advanced Gastrointestinal Cancer被引量：8: 《Chinese Medical Journal》2016年第18期2168-2172,共5页Ying-Ying Du Qiu-Jun Zhang Guo-Ping Sun; Background： As the clinical value of cytokeratin-19 （CK 19） and thymidine kinase-1 （TK1 ） in advanced gastrointestinal cancer remains controversial, we investigated their expression and clinical significance in t...; 关键词：Advanced Gastrointestinal Cancer CYTOKERATIN-19 Overall Survival Thymidine Kinase-1

Thymidine Glycol: The Effect on DNA Structure and DNA Binding by Site-Specific Proteins: 《Natural Science》2015年第11期491-509,共19页Elena A. Kubareva Fan Yang Alexandra Yu. Ryazanova Nina G. Dolinnaya Andrei V. Golovin Nikolai V. Molochkov Elena A. Romanova Elizaveta A. Karpova Timofei S. Zatsepin Tatiana S. Oretskaya; Thymidine glycol (5,6-dihydroxy-5,6-dihydrothymidine, Tg) is a major type of oxidative damage in DNA. During chemical oligonucleotide synthesis, Tg residue was incorporated in the different positions of 17 b.p. DNA du...; 关键词：THYMIDINE GLYCOL OXIDATIVE Damage Molecular Dynamics Simulations Nuclear Factor KAPPA-B DNA METHYLTRANSFERASE SsoII

大气压低温等离子体与胸腺嘧啶脱氧核苷的作用被引量：1: 《高电压技术》2015年第9期2837-2843,共7页杨思泽杨周斌周仁武张先徽; 福建省自然基金(2014J01025);国家自然科学基金(11275261)~~; 胸腺嘧啶(Thymine)是遗传物质的组成成分之一,为了研究等离子体对遗传胸腺嘧啶(Thymine)的作用过程,利用大气压等离子体对作为遗传物质的胸腺嘧啶(Thymine)及对应的胸腺嘧啶脱氧核苷(Thymidine)进行处理,为了避免空气对遗传物质的影响,...; 关键词：大气压冷等离子体含氧自由基胸腺嘧啶(Thymine) 胸腺嘧啶脱氧核苷(Thymidine) pH值色谱质谱

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