Experimental research on TECA-I bioartificial liver support system to treat canines with acute liver failure  

作　　者：Xiao-Ping Chen~2 Yi-Long Xue~1 Xin-Jian Li~1 Zuo-Yun Zhang~1 Yan-Ling Li~1 Zhi-Qiang Huang~2 1 Institute of Basic Medical Sciences,2 Department of Hepatobiliary Surgery,PLA General Hospital,Beijing 100853,China 

出　　处：《World Journal of Gastroenterology》2001年第5期706-709,共4页世界胃肠病学杂志（英文版）

摘　　要：AIM: To evaluate the efficacy and safety of the TECA-I bioartificial liver support system (BALSS) in treating canines with acute liver failure (ALF). METHODS: Ten canines with ALF induced by 80% liver resection received BALSS treatment (BALSS group). Blood was perfused through a hollow fiber tube containing 1X10(10) porcine hepatocytes.Four canines with ALF were treated with BALSS without porcine hepatocytes (control group), and five canines with ALF received drug treatment (drug group). Each treatment lasted 6 hours. RESULTS: BALSS treatment yielded beneficial effects for partial liver resection induced ALF canines with survival and decreased plasma ammonia, ALT, AST and BIL. There was an obvious decrease in PT level and increase in PA level, and there were no changes in the count of lymphocytes, immunoglobulins (IgA, IgG and IgM) and complement (C3 and C4) levels after BALSS treatment. In contrast, for the canines with ALF in non-hepatocyte BALSS group (control group) and drug group, there were no significant changes in ammonia, ALT, AST, BIL, PT and PA levels. ALF canines in BALSS group, control group and drug group lived respectively an average time of 108.0h +/- 12.0h, 24.0h +/- 6.0h and 20.4h +/- 6.4h,and three canines with ALF survived in BALSS group. CONCLUSION: TECA-I BALSS is efficacious and safe for ALF canines induced by partial liver resection.AIM To evaluate the efficacy and safety of the TECA-lbioartificial liver support system (BALSS) in treating canines with acute liver failure (ALF).``METHODS Ten canines with ALF induced by 80% liver resection received BALSS treatment (BALSS group).Blood was perfused through a hollow fiber tube containing 1 1010 porcine hepatocytes. Four canines with ALF were treated with BALSS without porcine hepatocytes (control group), and five canines with ALF received drug treatment (drug group). Each treatment lasted 6 hours.``RESULTS BALSS treatment yielded beneficial effects for partial liver resection-induced ALF canines with survival and decreased plasma ammonia, ALT, AST and BIL. There was an obvious decrease in PT level and increase in PA level, and there were no changes in the count of lymphocytes, immunoglobulins (IgA, IgG and IgM) and complement (C3 and C4) levels after BALSS treatment. In contrast, for the canines with ALF in non-hepatocyte BALSS group (control group) and drug group, there were no significant changes in ammonia, ALT, AST, BIL, PT and PA levels. ALF canines in BALSS group, control group and drug group lived respectively an average time of 108.0 h _- 12.0 h, 24.0 h -+ 6.0 h and 20.4 h + 6.4 h, and three canines with ALF survived in BALSS group.``CONCLUSION TECA-I BALSS is efficacious and safe for ALF canines induced by parcial liver resection.

关 键 词：Liver  Artificial Animals Blood Coagulation DOGS HEPATECTOMY HEPATOCYTES Kidney LIVER Liver Failure  Acute Lung MYOCARDIUM Swine 

分 类 号：R575.3[医药卫生—消化系统]