膳食中n-3多不饱和脂肪酸对2型糖尿病患者血糖和胰岛素敏感性的影响  

Effect of dietary n-3 polyunsaturated fatty acids on blood glucose and insulin sensitivity in patients with type 2 diabetes

作　　者：郑钜圣[1] 袁继红[2] 李铎[1] 

机构地区：[1]浙江大学,食品科学与营养学杭州310058 [2]解放军总医院营养一室,北京100853

出　　处：《食品安全质量检测学报》2012年第5期379-382,共4页Journal of Food Safety and Quality

基　　金：国家自然科学基金项目(81273054/H2603)

摘　　要：2型糖尿病是世界上最常见的慢性疾病之一。膳食中的n-3多不饱和脂肪酸可能会减少亚洲人的2型糖尿病风险,中国2型糖尿病患者血浆磷脂n-3不饱和脂肪酸与胰岛素敏感性呈正相关。而欧美的前瞻性研究均发现,鱼类的摄入和n-3多不饱和脂肪酸的摄入会增加2型糖尿病的发病风险,在西方白种人群中进行的n-3多不饱和脂肪酸干预的随机对照试验也并未发现n-3多不饱和脂肪酸能够改善患者胰岛素抵抗水平或血糖水平,n-3多不饱和脂肪酸甚至可轻微地降低患者胰岛素的敏感性。本文综述了目前n-3多不饱和脂肪酸摄入量与2型糖尿病风险之间的关系。Type 2 diabetes is one of the most common chronic diseases in the world.Dietary n-3 polyunsaturated fatty acids(n-3 PUFA) might decrease risk of type 2 diabetes in Asians,and plasma phospholipids n-3 PUFA were positively associated with insulin sensitivity in Chinese type 2 diabetes patients.Prospective study in Europe and the United States found that the intake of fish and n-3 PUFA intake increased the risk of type 2 diabetes,the Western Caucasian n-3 PUFA acid randomized controlled trials found that n-3 PUFA could not improve insulin resistance and blood sugar levels,and n-3 PUFA even slightly reduced the patient's insulin sensitivity.This paper summarised the current insight of the relatioship between dietary n-3 PUFA intake and type 2 diabetes risk.

关 键 词：N-3多不饱和脂肪酸 2型糖尿病 胰岛素抵抗 胰岛素敏感性 血糖 

分 类 号：R587.1[医药卫生—内分泌]