The metabolic switch and its regulation in cancer cells  

作　　者：ZHOU ShengTao, HUANG CanHua & WEI YuQuan State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China 

出　　处：《Science China(Life Sciences)》2010年第8期942-958,共17页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of Chi-na (Grant No. 2011CB910703);the National High-Tech Research and Development Program of China (Grant No. 2007AA021205)

摘　　要：The primary features of cancer are maintained via intrinsically modified metabolic activity, which is characterized by enhanced nutrient supply, energy production, and biosynthetic activity to synthesize a variety of macromolecular components during each passage through the cell cycle. This metabolic shift in transformed cells, as compared with non-proliferating cells, in-volves aberrant activation of aerobic glycolysis, de novo lipid biosynthesis and glutamine-dependent anaplerosis to fuel robust cell growth and proliferation. Here, we discuss the unique metabolic characteristics of cancer, the constitutive regulation of metabolism through a variety of signal transduction pathways and/or enzymes involved in metabolic reprogramming in cancer cells, and their implications in cancer diagnosis and therapy.The primary features of cancer are maintained via intrinsically modified metabolic activity, which is characterized by enhanced nutrient supply, energy production, and biosynthetic activity to synthesize a variety of macromolecular components during each passage through the cell cycle. This metabolic shift in transformed cells, as compared with non-proliferating cells, in-volves aberrant activation of aerobic glycolysis, de novo lipid biosynthesis and glutamine-dependent anaplerosis to fuel robust cell growth and proliferation. Here, we discuss the unique metabolic characteristics of cancer, the constitutive regulation of metabolism through a variety of signal transduction pathways and/or enzymes involved in metabolic reprogramming in cancer cells, and their implications in cancer diagnosis and therapy.

关 键 词：AEROBIC GLYCOLYSIS cancer de novo FATTY acid synthesis GLUTAMINOLYSIS metabolism 

分 类 号：R730.2[医药卫生—肿瘤]