Effects of two novel sugar drug candidates on CYP450 isoforms in different sexed Chinese human liver microsome in vitro  

作　　者：SHI Jie,ZHANG Xin-hui,SU Jia-ru(Pharmacy Department of Qingdao Municipal Hospital,5 Donghai Road,Qingdao 266071,China) 

出　　处：《沈阳药科大学学报》2008年第S1期121-122,共2页Journal of Shenyang Pharmaceutical University

摘　　要：The sex-based differences between the effects of two novel sugar-based drug candidates,a sulfated polymannuroguluronate(SPMG-911)and an acidic oligosaccharide sugar chain compound(AOSC-971),on the enzymes CYP 1A2,CYP2E1 and CYP3A4 of Chinese human liver microsome were investigated.The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP3A4,AOSC-971 induced the CYP 2E1 in men but have no effect on CYP1A2,SPMG-911 inhibit the CYP1A2 also in men but have no effect on CYP2E1.The results are useful for their safety evaluation,as well as for the prediction of inter-drug interactions associated with the two drugs.The sex-based differences between the effects of two novel sugar-based drug candidates,a sulfated polymannuroguluronate(SPMG-911)and an acidic oligosaccharide sugar chain compound(AOSC-971),on the enzymes CYP 1A2,CYP2E1 and CYP3A4 of Chinese human liver microsome were investigated.The results showed that neither SPMG-911 nor AOSC-971 have any effect on CYP3A4,AOSC-971 induced the CYP 2E1 in men but have no effect on CYP1A2,SPMG-911 inhibit the CYP1A2 also in men but have no effect on CYP2E1.The results are useful for their safety evaluation,as well as for the prediction of inter-drug interactions associated with the two drugs.

关 键 词：NOVEL SUGAR DRUG candidates CYP 450 enzymes human liver MICROSOME DRUG safety evaluation 

分 类 号：R96[医药卫生—药理学]