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Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease
《Neural Regeneration Research》2025年第11期3223-3224,共2页Tong Zhang Martina Schmidt 
supported by Alzheimer Nederland grant[WE.03-2019-05](to MS)。
Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and cognition.In the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy...
关键词：ALZHEIMER IMPAIRED AΒ 
PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation
《Neural Regeneration Research》2025年第7期1993-1994,共2页Anup Bhusal Won-Ha Lee Kyoungho Suk 
supported by a grant from the Basic Science Research Program through the National Research Foundation(NRF),which is funded by the Korean government(MSIP)(NRF-2020M3E5D9079764)(to KS)。
Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.
关键词：INFLAMMATION considerably 
Case report of a novel GREB1L gene mutation in a patient with branchio-oto-renal syndrome
《Journal of Otology》2025年第2期67-71,共5页Sijing Chen Zixuan Yang Maoxin Wang Cuiping Zhong 
Branchio-oto-renal(BOR)syndrome is an uncommon disorder inherited in an autosomal dominant manner.Its main clinical manifestations include branchial cleft cysts,anterior auricular fistula,hearing impairment,and kidney...
关键词：Branchio-oto-renal syndrome GREB1L Hearing loss Kidney agenesis 
Novel radiopaque ethanol injection:physicochemical properties,animal experiments,and clinical application in vascular malformations
《Military Medical Research》2025年第3期339-353,共15页Yu-Chen Shen De-Ming Wang Xi-Tao Yang Zhen-Feng Wang Ming-Zhe Wen Yi-Feng Han Lian-Zhou Zheng Ruo-Yu Di Chun-Yu Jiang Jing-Bing Wang Jian-Xiong You Li-Ming Zhang Li-Xin Su Xin-Dong Fan 
supported by the Transverse Research Project of Shanghai Ninth People’s Hospital(JYHX2022007);the Clinical Research Program of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(JYLJ202111).
Background:Despite the efficacy of absolute ethanol(EtOH),its radiolucency introduces several risks in interventional therapy for treating vascular malformations.This study aims to develop a novel radiopaque ethanol i...
关键词：Vascular malformation ETHANOL SCLEROTHERAPY RADIOPACITY IOPROMIDE Radiopaque ethanol injection(REI) 
A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy
《Genes & Diseases》2025年第3期76-79,共4页Wei Zhang Yibao Fan Milad Ashrafizadeh Dan Shi Gautam Sethi Yavuz Nuri Ertas AMAbd ElAty Xianbin Zhang Si Chen Peng Gong 
supported by the National Natural Science Foundation of China(No.82405167);the Shenzhen Science and Technology Program(Guangdong,China)(No.GJHZ20220913143005010);the fundamental research project of the Shenzhen Science and Technology Innovation Commission(No.20231120113324002 and No.RCBS20231211090635056).
Pancreatic cancer is one of the most lethal cancers worldwide and is characterized by a poor prognosis.1,2 Due to its aggressive nature and lack of early symptoms,most patients are diagnosed at an advanced stage,and c...
关键词：EPIDEMIOLOGY incidence rate pancreatic cancer resistance BUFALIN CHEMOTHERAPY novel bcat inhibitor prognosis 
A novel heuristic pathfinding algorithm for 3D security modeling and vulnerability assessment
《Nuclear Science and Techniques》2025年第5期152-166,共15页Jun Yang Yue-Ming Hong Yu-Ming Lv Hao-Ming Ma Wen-Lin Wang 
supported by the fundings from 2024 Young Talents Program for Science and Technology Thinking Tanks(No.XMSB20240711041);2024 Student Research Program on Dynamic Simulation and Force-on-Force Exercise of Nuclear Security in 3D Interactive Environment Using Reinforcement Learning,Natural Science Foundation of Top Talent of SZTU(No.GDRC202407);Shenzhen Science and Technology Program(No.KCXFZ20240903092603005);Shenzhen Science and Technology Program(No.JCYJ20241202124703004);Shenzhen Science and Technology Program(No.KJZD20230923114117032)。
Vulnerability assessment is a systematic process to identify security gaps in the design and evaluation of physical protection systems.Adversarial path planning is a widely used method for identifying potential vulner...
关键词：Physical protection system 3D modeling and simulation Vulnerability assessment A^(*)Heuristic Pathfinding Dijkstra algorithm 
Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic β cell regeneration and glucose uptake
《Chinese Journal of Natural Medicines》2025年第4期492-503,共12页Zhewei Yu Yi Zhang Wenhui Wang XinYi Wu Shunzhi Liu Yanlin Bin Hongsheng Li Bangping Cai Zheng Wang Meijuan Fang Rong Qi Mingyu Li Yingkun Qiu 
supported by the Traditional Chinese Medicine Foundation of Xiamen City,China(No.XWZY-2023-0303);the Natural Science Foundation of Xiamen City,China(No.3502Z20227162)。
In this study,araucarene diterpenes,characterized by a pimarene skeleton with a variably oxidized side chain at C-13,were investigated.A total of 16 araucarene diterpenoids and their derivatives were isolated from the...
关键词：Agathis dammara Araucarene DITERPENES HYPOGLYCEMIC Pancreatic β Cells 
Chaos-Based Novel Watermarked Satellite Image Encryption Scheme
《Computer Modeling in Engineering & Sciences》2025年第4期1049-1070,共22页Mohamed Medani Yahia Said Nashwan Adnan Othman Farrukh Yuldashev Mohamed Kchaou Faisal Khaled Aldawood Bacha Rehman 
supported by the Deanship of Scientific Research at King Khalid University for funding this work through the large group research project under grant number RGP2/461/45;the Deanship of Scientific Researchat Northern Border University,Arar,Saudi Arabia for funding this research work through the project number NBU-FFR-2025-3030-05.
Satellite images are widely used for remote sensing and defence applications,however,they are subject to a variety of threats.To ensure the security and privacy of these images,theymust be watermarked and encrypted be...
关键词：DNA sequence TD-ERCS chaoticmap henon chaoticmap duffing chaotic system SHA-512 encryption technique watermark embedding 
A Novel CAPTCHA Recognition System Based on Refined Visual Attention
《Computers, Materials & Continua》2025年第4期115-136,共22页Zaid Derea Beiji Zou Xiaoyan Kui Monir Abdullah Alaa Thobhani Amr Abdussalam 
supported by the National Natural Science Foundation of China(Nos.U22A2034,62177047);High Caliber Foreign Experts Introduction Plan funded by MOST,and Central South University Research Programme of Advanced Interdisciplinary Studies(No.2023QYJC020).
Improving website security to prevent malicious online activities is crucial,and CAPTCHA(Completely Automated Public Turing test to tell Computers and Humans Apart)has emerged as a key strategy for distinguishing huma...
关键词：Text-based CAPTCHA recognition refined visual attention web security computer vision 
Dystrophic epidermolysis bullosa caused by novel frameshift mutation in the COL7A1 gene: A case report
《World Journal of Clinical Cases》2025年第11期60-65,共6页Yan Yang Zhi-Wei Guan Qin-Feng Li 
BACKGROUND Dystrophic epidermolysis bullosa is characterized by fragile ulcerations of the skin caused by mutations in specific genes.However,genetic typing of this con-dition is rare.CASE SUMMARY An 11-year-old femal...
关键词：Dystrophic epidermolysis bullosa Frameshift mutation Genetic testing COL7A1 gene Genetic typing IMMUNOGLOBULIN Case report 
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