EFFECTS　OF　HYPOPHYSECTOMY　AND　GROWTH　HORMONE　REPLACEMENT　ON　HYPOTHALAMIC　SOMATOSTATIN　IN　THE　OLD　RAT  

作　　者：张樟进 任惠民 胡海涛 凌凤东 

出　　处：《Journal of Pharmaceutical Analysis》1994年第1期15-19,40,共6页药物分析学报（英文版）

摘　　要：Somatostatin (SS) content of the hypothalamic periventricular area (PVA) and themedian eminence (ME) and their changes following hypophysectomy (HYPOX) and HYPOX plus the administration of supraphysiological amount of growth hormone (GH) were compared between young (2￣4 months old) and old (22￣28 months old) male rats by radioimmunoassay. There was no marked difference in SS content of PVA in both age groups, while SS level in the old rat ME wasconsiderably lower than that in the young rat (P < 0. 01 ). Following HYPOX, SS content of PVA and ME was significantly reduced in both age groups. However, if compared with their control values,respectively, the reduction amplitude of the old rat is only 1/2 times as that of the young rat. InHYPOX+GH animals, if compared with their HYPOX values, respectively, a decrease in SS content in the PVA was not found in either age rat, but was remarkably elevated in the ME in both age groups,moreover, the elevated amplitude of the young rat was 2-fold as that of the old rat. These results suggest that the synthetic and release capacity as well as the response to the target hormone in the hypothalamic SS system of the male rat is progressively declined with increasing age.Somatostatin (SS) content of the hypothalamic periventricular area (PVA) and themedian eminence (ME) and their changes following hypophysectomy (HYPOX) and HYPOX plus the administration of supraphysiological amount of growth hormone (GH) were compared between young (2￣4 months old) and old (22￣28 months old) male rats by radioimmunoassay. There was no marked difference in SS content of PVA in both age groups, while SS level in the old rat ME wasconsiderably lower than that in the young rat (P < 0. 01 ). Following HYPOX, SS content of PVA and ME was significantly reduced in both age groups. However, if compared with their control values,respectively, the reduction amplitude of the old rat is only 1/2 times as that of the young rat. InHYPOX+GH animals, if compared with their HYPOX values, respectively, a decrease in SS content in the PVA was not found in either age rat, but was remarkably elevated in the ME in both age groups,moreover, the elevated amplitude of the young rat was 2-fold as that of the old rat. These results suggest that the synthetic and release capacity as well as the response to the target hormone in the hypothalamic SS system of the male rat is progressively declined with increasing age.

关 键 词：aging SOMATOSTATIN HYPOTHALAMUS RAT RADIOIMMUNOASSAY 

分 类 号：R584[医药卫生—内分泌]