EFFECTS OF ATROPINE ON THE CHANGES OF PAIN THRESHOLD AND CONTENTS OF LEUCINE-ENKEPHALIN AND CATECHOLAMINES OF THE BRAIN IN RATS INDUCED BY EA  

作　　者：王友京 王双坤 伍洁 

机构地区：[1]Institute of Acupuncture,China Academy of TCM,100700 Beijing

出　　处：《Journal of Traditional Chinese Medicine》1992年第2期137-141,共5页中医杂志（英文版）

摘　　要：After rats received electroacupuncture(EA),leucine-enkephalin(LEK) content in striatumand dopamine(DA)concentration in both brain stem and diencephalon markedly increased,and noradrenaline(NA)level in telencephalon definitely decreased with an obvious elevationof pain threshold.However,a previous intraperitoneal injection of atropine,a blocker ofmuscarinic receptor,not only partially blocked the analgesic effect of EA,but also changedthe effects of EA on LEK,NA and DA contents of the brain.The results indicate thatchollnergic system plays an important role in electroacupuncture analgesia (EAA),whichmay be fulfilled partially through the central LEK and catecholamine(CA)systems.After rats received electroacupuncture(EA),leucine-enkephalin(LEK) content in striatum and dopamine(DA)concentration in both brain stem and diencephalon markedly increased, and noradrenaline(NA)level in telencephalon definitely decreased with an obvious elevation of pain threshold.However,a previous intraperitoneal injection of atropine,a blocker of muscarinic receptor,not only partially blocked the analgesic effect of EA,but also changed the effects of EA on LEK,NA and DA contents of the brain.The results indicate that chollnergic system plays an important role in electroacupuncture analgesia (EAA),which may be fulfilled partially through the central LEK and catecholamine(CA)systems.

关 键 词：ANALGESIA ANALGESIC dopamine blocked markedly definitely partially BLOCKER minutes saline 

分 类 号：R[医药卫生]