THE EFFECTS OF PERFUSION OF LATERAL VENTRICLE WITH CaCl_2 ON THE FEBRILE RESPONSE AND cAMP CONTENT IN PLASMA AND CEREBROSPINAL FLUID DURING LP-INDUCED FEVER  

作　　者：张怡 李楚杰 

机构地区：[1]Department of Pathophysiology, Institute of Fever Research, Medical College, Jinan University

出　　处：《Science China Chemistry》1991年第3期317-326,共10页中国科学（化学英文版）

摘　　要：Artificial cerebrospinal fluid (c.s.f.) containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na^+/Ca^(++) ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate (cAMP) concentration in plasma and c.s.f, during leucocytic pyrogen (LP)-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na^+/Ca^(++) ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.Artificial cerebrospinal fluid （c.s.f.） containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na⁺/Ca⁺⁺ ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate （cAMP） concentration in plasma and c.s.f, during leucocytic pyrogen （LP）-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na⁺/Ca⁺⁺ ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.

关 键 词：ADENOSINE cyclic MONOPHOSPHATE sodium calcium PYROGEN FEVER 

分 类 号：O6[理学—化学]