Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma  

作　　者：Yuichi Sanada Yujo Kawashita Satomi Okada Takashi Azuma Shigetoshi Matsuo 

机构地区：[1]Department of Surgery, Nagasaki Prefecture Shimabara Hospital

出　　处：《World Journal of Gastrointestinal Pathophysiology》2014年第3期188-199,共12页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.

关 键 词：INTRAHEPATIC CHOLANGIOCARCINOMA Combined hepatocellular-cholangiocarcinoma Hepatic progenitor cells MACROSCOPIC SUBTYPE 

分 类 号：R735.7[医药卫生—肿瘤]