Role of sirtuins in ischemia-reperfusion injury  

作　　者：Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Joan Roselló-Catafau 

机构地区：[1]Experimental Hepatic Ischemia-Reperfusion Unit,Institut of Biomedical Research of Barcelona-Spanish National Research Council,Barcelona,08036 Catalonia,Spain [2]Molecular Biology and Anthropology applied to development and health (UR12ES11),Faculty of Pharmacy,Monastir 5000,Tunisia [3]Experimental Pathology Department,Institute of Biomedical Research of Barcelona-Spanish National Research Council,Barcelona,08036 Catalonia,Spain

出　　处：《World Journal of Gastroenterology》2013年第43期7594-7602,共9页世界胃肠病学杂志（英文版）

基　　金：Supported by AGAUR,No.2012FI_B00382,Generalitat de Catalunya,Barcelona,Spain,to Pantazi E;CSIC for the development program to Bejaoui M,No.I-COOP0005;The Fondo de Investigaciones Sanitarias,No.FIS PI12/00519

摘　　要：Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation.Several factors contribute to its complexity;the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury.Recently,the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers,due to their involvement in the modulation of a wide variety of cellular functions.There are seven mammalian sirtuins and,among them,the nuclear/cytoplasmic sirtuin 1(SIRT1)and the mitochondrial sirtuin 3(SIRT3)are ubiquitously expressed in many tissue types.Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways,which are key processes during IRI.In this review,we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress,apoptosis,microcirculatory stress and inflammation during reperfusion.We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action.Ischemia-reperfusion injury(IRI) remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation. Several factors contribute to its complexity; the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury. Recently,the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers,due to their involvement in the modulation of a wide variety of cellular functions. There are seven mammalian sirtuins and,among them,the nuclear/cytoplasmic sirtuin 1(SIRT1) and the mitochondrial sirtuin 3(SIRT3) are ubiquitously expressed in many tissue types. Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways,which are key processes during IRI. In this review,we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress,apoptosis,microcirculatory stress and inflammation during reperfusion. We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action.

关 键 词：SIRTUIN 1 SIRTUIN 3 ISCHEMIA-REPERFUSION INJURY OXIDATIVE stress APOPTOSIS 

分 类 号：R363[医药卫生—病理学]