Metastatic type 1 gastric carcinoid:A real threat or just a myth?  

作　　者：Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross 

机构地区：[1]Neuroendocrine Tumor Unit,Endocrinology and Metabolism Service,Department of Medicine,Hadassah-Hebrew University Medical Center [2]Endocrine Unit,Department of Pathophysiology,National University of Athens [3]Moffitt Cancer Center,Tampa [4]Department of Internal Medicine,Division of Hepatology,Gastroenterology,Endocrinology and Metabolism,Charité Universit tsmedizin [5]Department of Medical Sciences,Section of Endocrine Oncology,Uppsala University [6]Institute of Endocrinology,Soroka Ben Gurion University Hospital [7]Department of Surgery,Shaare-Zedek Medical Center,The Hebrew University School of Medicine

出　　处：《World Journal of Gastroenterology》2013年第46期8687-8695,共9页世界胃肠病学杂志（英文版）

摘　　要：AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels.AIM: To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1 (GCA1).

关 键 词：METASTATIC gastric CARCINOIDS GASTRIN Chro-mogranin A SOMATOSTATIN analogues Stomach neuro-endocrine tumor 

分 类 号：R735.2[医药卫生—肿瘤]