In vivo bone dynamic imaging of PTH's anabolic effect  

作　　者：Allison R.Altman Chantal de Bakker Wei-Ju Tseng Beom Kang Huh Abhishek Chandra Ling Qin X.Sherry Liu 

机构地区：[1]McKay Orthopaedic Research Laboratory,Department of Orthopaedic Surgery,Pereman School of Medicine,University of Pennsylvania

出　　处：《医用生物力学》2013年第S1期47-50,共4页Journal of Medical Biomechanics

基　　金：supported by McCabe pilot award and the Penn Center for Musculoskeletal Disorders(NIH/NIAMS P30AR050950)

摘　　要：Introduction Aging shifts bone remodeling toward a negative balance between bone formation and resorption,causing bone loss and increased fracture risk.Anti-resorptive agents are commonly used to inhibit bone resorption and stabilize bone mass.While they are effective to prevent further bone loss,there is also a great need for anabolic agents which can reverse bone deterioration and regain lost skeletal integrity.PTH,the only FDA-approved anabolic treatment for osteoporosis,greatly stimulates bone formation.Combined therapy of anti-resorptive treatments,such as alendronate(ALN),and PTH have been proposed and are expected to further increase bone mass.However,studies show conflicting results regarding the effectivenessIntroduction Aging shifts bone remodeling toward a negative balance between bone formation and resorption,causing bone loss and increased fracture risk.Anti-resorptive agents are commonly used to inhibit bone resorption and stabilize bone mass.While they are effective to prevent further bone loss,there is also a great need for anabolic agents which can reverse bone deterioration and regain lost skeletal integrity.PTH,the only FDA-approved anabolic treatment for osteoporosis,greatly stimulates bone formation.Combined therapy of anti-resorptive treatments,such as alendronate(ALN),and PTH have been proposed and are expected to further increase bone mass.However,studies show conflicting results regarding the effectiveness of

关 键 词：osteoporosis REMODELING TRABECULAR SKELETAL deterioration impaired INHIBIT stabilize approved HISTOLOGY 

分 类 号：R580[医药卫生—内分泌]