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作品数：498被引量：2134H指数：17
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Resveratrol inhibit the proliferation and migration of HepG2 cells through SIRT1-MAPK signaling pathway
《Food and Health》2025年第1期22-28,共7页Chen-Chen Feng Yi-Jiao Xu Yu Chen Wan-Wei Yang Xiao Wei Ren-Dong Zheng 
supported by Natural Science Foundation of Nanjing University of Chinese Medicine(XZR2023010);Traditional Chinese Medicine Science and Technology Project of Jiangsu Province(QN202212);Guidance Program of Jiangsu Commission of Health(Z2020046).
Background: Resveratrol is a widely recognized anti-inflammatory and antioxidant agent,and it has been suggested to possess anti-tumor effects. But the effect of resveratrol onhepatocellular carcinoma and its molecula...
关键词：RESVERATROL Hepatocellular carcinoma HepG2 cells SIRT1 MAPK 
The 21-base pair deletion mutant Calpain3 does not inhibit wild-type Calpain3 activity
《Genes & Diseases》2025年第1期52-55,共4页Swati Maitra Seungjae Oh Yun-Jeong Choe JiHye Kim Nam Chul Kim 
supported by grants from the Muscular Dystrophy Association and the Wallin Neuroscience Discovery Fund and the Engebretson Drug Design and Discovery Fund(to Nam Chul Kim).
Calpain3 is one of the calpain protease family members that are predominantly expressed in skeletal muscle.Lossof-function mutations in Calpain3 have been related to autosomal recessive limb-girdle muscular dystrophy ...
关键词：CATALYTIC BASE function 
Garlic-derived nanoparticles inhibit tumor by activating tumor infiltrating γδT cells
《Nano Research》2025年第2期586-593,共8页Jialu Xu Jintao Huang Yue Yu Di Hu Yue Zhang Huaxing Dai Li You Fang Xu Jian Shen Chao Wang 
This work was supported by the National Key R&D Program of China(No.2022YFB3808100);the National Natural Science Foundation of China(No.32371476)。
γδT cells have emerged as a promising target in tumor therapy,prompting the development of novel strategies to activate these cells directly within the tumor microenvironment.In this study,we engineered uniformly si...
关键词：garlic-derived nanoparticles γδT cells tumor microenvironment antitumor effects 
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
《Acta Pharmaceutica Sinica B》2025年第2期876-891,共16页Yuyu Zhu Lixin Zhao Wei Yan Hongyue Ma Wanjun Zhao Jiao Qu Wei Zheng Chenyang Zhang Haojie Du Meng Yu Ning Wan Hui Ye Yicheng Xie Bowen Ke Qiang Xu Haiyan Sun Yang Sun Zijun Ouyang 
supported by the National Key Research and Development Plan(2022YFC3500202,China);the National Natural Science Foundation of China(Nos.82230116,81872877,82204715,81803142,82404639,and 82073975);the Natural Science Foundation of Jiangsu Province(No.BK20220476,China);the Jiangsu Provincial Double-Innovation Doctor Program(No.JSSCBS20220477,China);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.XPT82204715,China);the Fundamental Research Funds for the Central Universities(Nos.020814380179 and 020814380174,China);the Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.22KJB360005);the Innovation Project of Guangdong Provincial Education Department(No.2023KTSCX320,China);the Shenzhen Science and Technology Program(Nos.20231126130044001 and 20230731094501002,China);the School of Life Science(NJU)-Sipimo Joint Funds,and the Mountain-Climbing Talents Project of Nanjing.
Psoriasis is an incurable chronic inflammatory disease that requires new interventions.Here,we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-c...
关键词：PSORIASIS FIBROBLAST CCL2 CELASTROL LRP1 MACROPHAGE C-JUN Drug target 
A novel Au(III)agent designed to inhibit tumor growth and metastasis through inducing immunogenic cell death
《Rare Metals》2025年第1期430-443,共14页Wen-Juan Li Shan-He Li Xue-Yu Man Gang Xu Zhen-Lei Zhang Yao Zhang Hong Liang Feng Yang 
supported by the Natural Science Foundation of Guangxi(No.2022GXNSFGA035003);the National Natural Science Foundation of China(No.22077021).
To treat cancer and inhibit its metastasis to the greatest extent,we proposed to develop an Au(III)agent to induce immunogenic cell death(ICD)and establish long-term immunity.To this end,we optimized a series of Au(II...
关键词：Gold complex ANTICANCER THIOSEMICARBAZONE Endoplasmic reticulum stress Immunogenic cell death 
Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma
《Oncology Research》2025年第1期199-212,共14页WEN YANG BIN TANG DAN XU WENXIU YANG 
supported by the Key Research and Development Program of Science and Technology Department of Guizhou Province(No.20204Y147).
Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported previously.However,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its int...
关键词：CCR7 CCL21 ERK1/2 LENALIDOMIDE Diffuse large B-cell lymphoma(DLBCL) 
Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress
《World Journal of Diabetes》2025年第1期91-103,共13页Zhi-Min Lin Han-Yuan Gao Shu-Han Shi Yue-Ting Li 
BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for diabetes.AIM To explore the impact of MIZ on diabetic nephropathy(DN).METHODS...
关键词：Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells 
Florfenicol can inhibit chick growth and lead to immunosuppression
《Journal of Integrative Agriculture》2025年第1期261-271,共11页Fanliang Meng Kuihao Liu Yesheng Shen Peixun Li Tailong Wang Yiran Zhao Sidang Liu Mengda Liu Gang Wang 
Florfenicol(FLO)is a chemically synthesized broad-spectrum antimicrobial agent of amide alcohols for animals,which is one of the most widely used antimicrobials in livestock,poultry,and aquaculture.With the use of FLo...
关键词：FLORFENICOL chick growth IMMUNOSUPPRESSION interferon-related genes CYTOKINES 
Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy
《Virologica Sinica》2024年第6期892-908,共17页Lihong Huang Lele Liu Junhai Zhu Nanjun Chen Jie Chen Chuen-Fuk Chan Fei Gao Youqin Yin Jiufeng Sun Rongxin Zhang Kehui Zhang Wenbao Qi Jianbo Yue 
supported by the National Key Research and Development Program of China(2022YFD1800100);the National Natural Science Foundation of China(32302843,32070702,and 82161128014);GuangDong Basic and Applied Basic Research Foundation(2023A1515010748);Innovation and Technology Fund of Hong Kong(MRP/064/21,GHP/097/20GD,and MHP/072/21);Hong Kong Research Grant Council(RGC)grant(11103620 and 11104422);research grants from Shenzhen Science and Technology Innovation Committee(SGDX20201103093201010 and JCYJ20210324134007020);Kunshan Shuang Chuang Grant(kssc202302073);the Kunshan Municipal Government research funding。
Flaviviruses,such as dengue virus(DENV),Zika virus(ZIKV),and Japanese encephalitis virus(JEV),represent a substantial public health challenge as there are currently no approved treatments available.Here,we investigate...
关键词：Bis-benzylisoquinoline alkaloids(BBAs) FLAVIVIRUS Zika virus(ZIKV) Endolysosomes TRPML channels AUTOPHAGY 
A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy
《Bioactive Materials》2024年第12期165-177,共13页Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang 
supported by the Shenzhen Science and Technology Program-Basic Research Scheme(JCYJ20220531090808020);the Research Grants Council(RGC)of Hong Kong Collaborative Research Grant(C5005-23W and C5078-21E);the Research Grants Council(RGC)of Hong Kong General Research Grant(PolyU 15217621 and PolyU 15216622);the Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/032/20SZ and SGDX20201103095404018);the Hong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund(I2022A002);PolyU Internal Fund(1-YWB4,1-WZ4E,1-CD8M,1-WZ4E,1-CEB1,1-YWDU,1-CE2J and 1-W02C);the funding from the Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center(No.:LMDBCXRC202401 and LMDBCXRC202402);Shandong Provincial Overseas Excellent Young Scholar Program(2024HWYQ-042 and 2024HWYQ-043);Taishan Scholar Youth Expert Program of Shandong Province(tsqn202306102 and tsqn202312105)supporting this work;supported by the University Research Facility in Life Sciences of the Hong Kong Polytechnic University.
Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen speci...
关键词：Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease 
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