Lanthanides-Induced Cellular Signal Transduction: Implications in Pathogenesis of Fibrosis  

作　　者：HE Xia GUO Yuting DONG Faqing WANG Kui YU Siwang 

机构地区：[1]Department of Chemical Biology,Peking University School of Pharmaceutical Sciences [2]School of environmental resource and engineering,SWUST

出　　处：《矿物学报》2013年第S1期34-34,共1页Acta Mineralogica Sinica

摘　　要：With the extensive mining and application of lanthanides in China and worldwide, the potential impact of lanthanides on human health is gaining increasing attentions. The recent etiological association of gadolinium-based contrast agents with nephrogenic systemic fibrosis (NSF) evoked widespread concerns regarding the safety issue of lanthanides. The elucidation of the cellular biological effects of and the signalling cascade induced lanthanides is essential for proper evaluation of their health impacts.With the extensive mining and application of lanthanides in China and worldwide, the potential impact of lanthanides on human health is gaining increasing attentions. The recent etiological association of gadolinium-based contrast agents with nephrogenic systemic fibrosis (NSF) evoked widespread concerns regarding the safety issue of lanthanides. The elucidation of the cellular biological effects of and the signalling cascade induced lanthanides is essential for proper evaluation of their health impacts.

关 键 词：GADOLINIUM LANTHANUM nephrogenic SYSTEMIC FIBROSIS HEK 293 Cell cycle EGFR PI3K/Akt MAPK TGFΒ-1 IntegrinαVβ1 

分 类 号：R363[医药卫生—病理学]