Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma  

作　　者：Yasunobu Matsuda Toshifumi Wakai Masayuki Kubota Mami Osawa Ayumi Sanpei Shun Fujimaki 

机构地区：[1]Department of Medical Technology, Niigata University Graduate Schoo of Health Sciences [2]Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences [3]Division of Pediatric Surgery,Niigata University Graduate School of Medical and Dental Sciences

出　　处：《World Journal of Gastroenterology》2013年第17期2587-2590,共4页世界胃肠病学杂志（英文版）

摘　　要：Hepatocellular carcinoma (HCC) is a common malignant disease with poor prognosis. To improve the clinical outcome, early diagnosis of HCC arising from nonviral agents and hepatitis virus is important. Among several etiological factors, mycotoxins defined as carcinogens by the International Agency for Research in Cancer (IARC) might be one of the critical risk factors for nonviral HCC. Aflatoxin B1 is the most well-known carcinogenic mycotoxin for HCC, but the role of the other types of mycotoxin remains unclear. Several studies have reported that a chromatographic separation technique based on high-performance liquid chromatography can successfully detect the concentration of mycotoxins in plasma. Recently, serum level of ochratoxin A (OTA), a widely distributed mycotoxin classified as Group 2B by IARC, was evaluated in HCC patients in Egypt. The results suggested that serum OTA levels might be a good biomarker for HCC. In this article, we review recent studies of OTA, and discuss its possible significance as a biomarker of HCC.Hepatocellular carcinoma (HCC) is a common malignant disease with poor prognosis. To improve the clinical outcome, early diagnosis of HCC arising from nonviral agents and hepatitis virus is important. Among several etiological factors, mycotoxins defined as carcinogens by the International Agency for Research in Cancer might be one of the critical risk factors for nonviral HCC. Aflatoxin B1 is the most well-known carcinogenic mycotoxin for HCC, but the role of the other types of mycotoxin remains unclear. Several studies have reported that a chromatographic separation technique based on high-performance liquid chromatography can successfully detect the concentration of mycotoxins in plasma. In this article, we review recent studies of mycotoxin, and discuss its possible significance as a biomarker of HCC.

关 键 词：HEPATOCELLULAR CARCINOMA MYCOTOXIN AFLATOXIN OCHRATOXIN High-performance liquid CHROMATOGRAPHY 

分 类 号：R735.7[医药卫生—肿瘤]