Atypical presentation of pseudomembranous colitis localized in adenomatous polyps  

作　　者：Cristian Hernández-Rocha Jonathan Barra-Carrasco Ana María Guzmán Daniel Paredes-Sabja Gabriel Lezcano Pablo Zoroquiaín Manuel lvarez-Lobos 

机构地区：[1]Department of Gastroenterology,Faculty of Medicine,Pontificia Universidad Católica de Chile,Marcoleta 367,Santiago 6510260,Chile [2]Laboratory of Mechanisms of Bacterial Pathogenesis,Department of Biological Sciences,Faculty of Biological Sciences,Universidad Andrés Bello,Santiago 6618000,Chile [3]Department of Clinical Laboratory,Faculty of Medicine,Pontificia Universidad Católica de Chile,Marcoleta 367,Santiago 6510260,Chile [4]Department of Biomedical Sciences,College of Veterinary Medicine,Oregon State University,Corvallis,OR 97333,United States [5]Department of Anatomophatology,Faculty of Medicine,Pontificia Universidad Católica de Chile,Marcoleta 367,Santiago 6510260,Chile

出　　处：《World Journal of Gastroenterology》2013年第2期316-318,共3页世界胃肠病学杂志（英文版）

摘　　要：The most frequent cause of pseudomembranous colitis is Clostridium difficile(C.difficile) infection.This type of colitis is characterized by an endoscopic pattern of numerous small,yellowish or whitish plaques diffusely distributed,which typically compromises the rectum extending to proximal colon.Occasionally,the pseudomembranes compromise only the transverse or right colon,but their exclusive localization over polyps has not been reported.In this case report we have described a patient with symptoms compatible with C.difficile infection and positive for C.difficile toxigenic culture.Colonoscopy examination showed two small polyps with a whitish surface,and histopathological analysis confirmed them to be pseudomembranes over tubular adenomas.The rest of the colonic mucosa was normal and no other cause was demonstrated.We suggest that this particular distribution might be due to a higher affinity for dysplastic cells such as adenomatous polyps of colon by C.difficile and/or its toxins.The most frequent cause of pseudomembranous colitis is Clostridium difficile (C. difficile) infection. This type of colitis is characterized by an endoscopic pattern of numerous small, yellowish or whitish plaques diffusely distributed, which typically compromises the rectum extending to proximal colon. Occasionally, the pseudomembranes compromise only the transverse or right colon, but their exclusive localization over polyps has not been reported. In this case report we have described a patient with symptoms compatible with C. difficile infection and positive for C. difficile toxigenic culture. Colonoscopy examination showed two small polyps with a whitish surface, and histopathological analysis confirmed them to be pseudomembranes over tubular adenomas. The rest of the colonic mucosa was normal and no other cause was demonstrated. We suggest that this particular distribution might be due to a higher affinity for dysplastic cells such as adenomatous polyps of colon by C. difficile and/or its toxins.

关 键 词：CLOSTRIDIUM DIFFICILE PSEUDOMEMBRANOUS COLITIS Adenomatous POLYPS Antibiotic-associated COLITIS CLOSTRIDIUM DIFFICILE INFECTIONS 

分 类 号：R574[医药卫生—消化系统]